Chronic unpredictable stress promotes neuronal apoptosis in the cerebral cortex.
Chronic unpredictable stress promotes neuronal apoptosis in the cerebral cortex.
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DOI：
10.1016/j.neulet.2008.06.081
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发表时间：
2008-09-12
影响因子：
2.5
通讯作者：
Mocchetti I
中科院分区：
文献类型：
--
作者：
Bachis A;Cruz MI;Nosheny RL;Mocchetti I
压力导致的海马区突触生成丧失似乎在抑郁症和情绪障碍中起着作用。然而，应激/抑郁对大脑皮层神经元的可塑性和存活率的影响却知之甚少。在这份报告中，我们研究了慢性应激是否会增加大鼠皮质神经元的脆弱性。我们使用了一种慢性不可预测的轻度应激(CMS)作为抑郁症的大鼠模型。CMS(治疗5周)导致贫血和皮质酮水平升高。伴随着这些效应的是大脑皮层中caspase-3阳性神经元的明显增加，这表明细胞凋亡。地昔帕明是一种著名的抗抑郁药，它逆转了CMS的促凋亡作用。这些结果表明，抗抑郁药可能会减轻应激诱导的抑郁障碍的病理变化。
Stress-mediated loss of synaptogenesis in the hippocampus appears to play a role in depressive and mood disorders. However, little is known about the effect of stress/depression on the plasticity and survival of cortical neurons. In this report, we have examined whether chronic stress increases the vulnerability of neurons in the rat cortex. We have used a chronic unpredictable mild stress (CMS) as a rat model of depression. CMS (5 weeks treatment) produced anedonia and increased corticosterone levels. These effects were accompanied by a detectable increase in caspase-3 positive neurons in the cerebral cortex, suggesting apoptosis. Desipramine, a well known antidepressant, reversed the pro-apoptotic effect of CMS. These results suggest that antidepressants may reduce the pathological changes seen in stress-induced depressive disorders.
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影响因子：
3.4
作者：
Merali, Z;Brennan, K;Anisman, H
通讯作者：
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影响因子：
16.2
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ANKARCRONA, M;DYPBUKT, JM;NICOTERA, P
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