Effects of Dietary Fructose Restriction on Liver Fat, De Novo Lipogenesis, and Insulin Kinetics in Children With Obesity.
Effects of Dietary Fructose Restriction on Liver Fat, De Novo Lipogenesis, and Insulin Kinetics in Children With Obesity.
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DOI：
10.1053/j.gastro.2017.05.043
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发表时间：
2017-09
期刊：
影响因子：
29.4
通讯作者：
Mulligan K
中科院分区：
文献类型：
--
作者：
Schwarz JM;Noworolski SM;Erkin-Cakmak A;Korn NJ;Wen MJ;Tai VW;Jones GM;Palii SP;Velasco-Alin M;Pan K;Patterson BW;Gugliucci A;Lustig RH;Mulligan K
糖的摄入与肥胖、2型糖尿病、非酒精性脂肪肝和心血管疾病有关。果糖在肝脏中转化为脂肪（从头脂肪生成，DNL）可能是一个可改变的致病途径。我们确定了9天的等热量果糖限制对DNL，肝脏脂肪，内脏脂肪（VAT），皮下脂肪和胰岛素动力学的影响，在肥胖的拉丁美洲和非洲裔美国儿童习惯性高糖消费（果糖摄入量超过50克/天）。儿童（9 - 18岁; n = 41）的所有膳食提供了9天，与他们的标准饮食相同的能量和常量营养素组成，但用淀粉代替糖，最终果糖含量为总千卡的4%。在果糖限制前后进行代谢评估。通过磁共振波谱和成像确定肝脏脂肪、VAT和皮下脂肪。使用稳定同位素示踪剂和气相色谱/质谱法测量分数DNL曲线下面积值。通过口服葡萄糖耐量试验计算胰岛素动力学。配对分析比较了每个孩子从第0天到第10天的变化。与基线相比，在第10天，肝脏脂肪从中位数7.2%（四分位数间距，2.5%-14.8%）至3.8%（四分位数间距，1.7%-15.5%）（P <0.001），VAT从123 cm 3（四分位距，85 - 145 cm 3）降至110 cm 3（四分位距，84 - 134 cm 3）（P <0.001）。DNL曲线下面积从68%（四分位距46%~83%）下降到26%（四分位距16%~37%）（P <0.001）。胰岛素动力学改善（P <.001）。这些变化的发生与基线肝脏脂肪无关。短期（9天）等热量果糖限制降低了肥胖儿童的肝脏脂肪、VAT和DNL，并改善了胰岛素动力学。这些发现支持减少糖消费的努力。ClinicalTrials.gov
Consumption of sugar is associated with obesity, type 2 diabetes mellitus, non-alcoholic fatty liver disease, and cardiovascular disease. The conversion of fructose to fat in liver (de novo lipogenesis, DNL) may be a modifiable pathogenetic pathway. We determined the effect of 9 days of isocaloric fructose restriction on DNL, liver fat, visceral fat (VAT), subcutaneous fat, and insulin kinetics in obese Latino and African American children with habitual high sugar consumption (fructose intake more than 50 g/day). Children (9–18 years old; n = 41) had all meals provided for 9 days with the same energy and macronutrient composition as their standard diet, but with starch substituted for sugar, yielding a final fructose content of 4% of total kcal. Metabolic assessments were performed before and after fructose restriction. Liver fat, VAT, and subcutaneous fat were determined by magnetic resonance spectroscopy and imaging. The fractional DNL area under the curve value was measured using stable isotope tracers and gas chromatography/mass spectrometry. Insulin kinetics were calculated from oral glucose tolerance tests. Paired analyses compared change from day 0 to day 10 within each child. Compared with baseline, on day 10, liver fat decreased from a median of 7.2% (inter-quartile range, 2.5%–14.8%) to 3.8% (inter-quartile range, 1.7%–15.5%)(P<.001) and VAT decreased from 123 cm3 (inter-quartile range, 85–145 cm3) to 110 cm3 (inter-quartile range, 84–134 cm3) (P<.001). The DNL area under the curve decreased from 68% (inter-quartile range, 46%–83%) to 26% (inter-quartile range, 16%–37%) (P<0.001). Insulin kinetics improved (P<.001). These changes occurred irrespective of baseline liver fat. Short-term (9 day) isocaloric fructose restriction decreased liver fat, VAT, and DNL, and improved insulin kinetics in children with obesity. These findings support efforts to reduce sugar consumption. ClinicalTrials.gov no: NCT01200043
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影响因子：
29.4
作者：
Lambert JE;Ramos-Roman MA;Browning JD;Parks EJ
通讯作者：
Parks EJ
异位脂肪、胰岛素抵抗和非酒精性脂肪肝对心血管疾病的影响
DOI：
10.1161/atvbaha.114.303034
发表时间：
2014-06-01
影响因子：
8.7
作者：
Byrne, Christopher D.;Targher, Giovanni
通讯作者：
Targher, Giovanni
影响因子：
5.8
作者：
Hudgins, Lisa C.;Parker, Thomas S.;Hellerstein, Marc K.
通讯作者：
Hellerstein, Marc K.
影响因子：
13.5
作者：
Birkenfeld, Andreas L.;Shulman, Gerald I.
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Shulman, Gerald I.
影响因子：
13.5
作者：
Cali, Anna M. G.;De Oliveira, Ana Mayra;Kim, Hyeonjin;Chen, Shu;Reyes-Mugica, Miguel;Escalera, Sandra;Dziura, James;Taksali, Sara E.;Kursawe, Romy;Shaw, Melissa;Savoye, Mary;Pierpont, Bridget;Constable, R. Todd;Caprio, Sonia
通讯作者：
Caprio, Sonia