Glucose dysregulation and hepatic steatosis in obese adolescents: is there a link?
Glucose dysregulation and hepatic steatosis in obese adolescents: is there a link?
复制标题
DOI：
10.1002/hep.22858
复制
发表时间：
2009-06
期刊：
影响因子：
13.5
通讯作者：
Caprio, Sonia
中科院分区：
文献类型：
--
作者：
Cali, Anna M. G.;De Oliveira, Ana Mayra;Kim, Hyeonjin;Chen, Shu;Reyes-Mugica, Miguel;Escalera, Sandra;Dziura, James;Taksali, Sara E.;Kursawe, Romy;Shaw, Melissa;Savoye, Mary;Pierpont, Bridget;Constable, R. Todd;Caprio, Sonia
脂肪肝在肥胖青少年中越来越常见。我们在118例(37m/81F)肥胖青少年中确定了它与糖代谢紊乱的关系，这些青少年的年龄和总脂肪百分比都很接近。用快速磁共振成像和单纯磁共振成像对肝脏脂肪含量和腹部脂肪分布进行量化。所有受试者都有标准的OGTT。用松田指数和HOMA-IR评价胰岛素敏感性。检测基线总、HMW-脂联素和IL-6水平。根据肝脏脂肪含量的不同对队列进行分层。虽然年龄和脂肪百分比在不同地区是相似的，但种族不同，黑人较少，白人和西班牙裔更多，属于中度和重度肾功能衰竭。内脏和内脏与皮下脂肪的比率增加，胰岛素敏感性降低。随着肝脏脂肪变性的加重，两小时血糖升高(p<；0.008)。高HFF组有73.7%的受试者患有代谢综合征，而低、中度组分别为19.5%和30.6%。随着肝脏脂肪变性程度的加重，总脂联素和HMW-脂联素均降低，IL-6升高。在肥胖青少年中，与总脂肪无关，脂肪肝的严重程度与葡萄糖调节失调、代谢综合征和促炎环境有关。
Fatty liver is increasingly common in obese adolescents. We determined its association with glucose dysregulation in 118 (37M/81F) obese adolescents of similar age and % total fat. Fast-MRI and simple MRI were used to quantify hepatic fat content and abdominal fat distribution. All subjects had a standard OGTT. Insulin sensitivity was estimated by the Matsuda Index and HOMA-IR. Baseline total and HMW-adiponectin and IL-6 levels were measured. The cohort was stratified according to tertiles of Hepatic Fat Content. While age and %fat were comparable across tertiles, ethnicity differed in that fewer Blacks and more Whites and Hispanics were in the Moderate and High category of HFF. Visceral and the visceral to subcutaneous fat ratio increased and insulin sensitivity decreased across tertiles. Two hr plasma glucose rose with increasing hepatic steatosis (p<0.008). 73.7% of the subjects in the High HFF had the Metabolic Syndrome compared to 19.5% and 30.6% respectively in the Low and Moderate category. Both total and HMW-adiponectin decreased, and IL-6 increased with increasing hepatic steatosis. In obese adolescents, independent of total fat, increasing severity of fatty liver is associated with glucose dysregulation, the Metabolic Syndrome and with a pro-inflammatory milieu.
登录
查看更多内容
影响因子：
24.5
作者：
Kaser, S;Moschen, A;Tilg, H
通讯作者：
Tilg, H
影响因子：
2.9
作者：
Fishbein, M;Castro, F;Stevens, WR
通讯作者：
Stevens, WR
DOI：
10.1097/01.mpg.0000164698.03164.e5
发表时间：
2005-07-01
影响因子：
2.9
作者：
Nadeau, KJ;Klingensmith, T;Zeitler, T
通讯作者：
Zeitler, T
影响因子：
5.8
作者：
Seppälä-Lindroos, A;Vehkavaara, S;Yki-Järvinen, H
通讯作者：
Yki-Järvinen, H
影响因子：
6.7
作者：
Schwenzer, Nina F.;Machann, Juergen;Schick, Fritz
通讯作者：
Schick, Fritz