The role of gut microbiota in the development of type 1, type 2 diabetes mellitus and obesity.
The role of gut microbiota in the development of type 1, type 2 diabetes mellitus and obesity.
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DOI：
10.1007/s11154-015-9309-0
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发表时间：
2015-03
影响因子：
8.2
通讯作者：
Wen, Li
中科院分区：
文献类型：
--
作者：
Tai, Ningwen;Wong, F. Susan;Wen, Li
糖尿病是一组以持续性高血糖为特征的代谢性疾病，已成为主要的公共卫生问题。自身免疫性1型糖尿病(T1D)和胰岛素抵抗2型糖尿病(T2D)是主要的两种类型。遗传和环境因素共同促成了这些疾病的发展。最近，肠道微生物区系在T1D、肥胖症和T2D的发展中扮演着重要的角色。在啮齿动物模型和人类中，肠道微生物区系的改变都与疾病有很强的联系。经典的16S rRNA测序和火枪式超基因组焦糖测序分析都被成功地应用于探索肠道微生物区系的组成和功能。本文综述了肠道微生物区系与糖尿病的关系，并讨论了肠道微生物区系调控1型糖尿病、肥胖症和2型糖尿病疾病发展的可能机制。
Diabetes is a group of metabolic disorders characterized by persistent hyperglycemia and has become a major public health concern. Autoimmune type 1 diabetes (T1D) and insulin resistant type 2 diabetes (T2D) are the two main types. A combination of genetic and environmental factors contributes to the development of these diseases. Gut microbiota have emerged recently as an essential player in the development of T1D, obesity and T2D. Altered gut microbiota have been strongly linked to disease in both rodent models and humans. Both classic 16S rRNA sequencing and shot-gun metagenomic pyrosequencing analysis have been successfully applied to explore the gut microbiota composition and functionality. This review focuses on the association between gut microbiota and diabetes and discusses the potential mechanisms by which gut microbiota regulate disease development in type 1 diabetes, obesity and type 2 diabetes.
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