The severity and risk factors for mortality in immunocompromised adult patients hospitalized with influenza-related pneumonia.
The severity and risk factors for mortality in immunocompromised adult patients hospitalized with influenza-related pneumonia.
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DOI：
10.1186/s12941-021-00462-7
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发表时间：
2021-08-24
影响因子：
5.7
通讯作者：
Xing X
中科院分区：
文献类型：
--
作者：
Chen L;Han X;Li Y;Zhang C;Xing X
探讨因流感相关肺炎（Flu-p）住院的成人免疫功能低下（IC）患者的疾病严重程度和30天死亡率的危险因素。2012年1月至2018年12月期间，从中国5家教学医院回顾性招募了122例IC和1191例因Flu-p住院的免疫功能正常患者。在控制混杂因素后，多变量logistic回归分析显示，免疫抑制与有创通气风险增加相关[比值比：（OR）2.475，95%可信区间（CI）：1.511-4.053，p < 0.001]，进入重症监护室（OR：3.247，95% CI 2.064-5.106，p < 0.001）和30天死亡率（OR：3.206，95%CI 1.926-5.335，p < 0.001）。另一个多变量Logistic回归模型显示基线淋巴细胞计数与基线淋巴细胞计数相关。（OR：0.993，95% CI 0.990-0.996，p < 0.001），合并感染（或：5.450，95%CI 1.638-18.167，p = 0.006），早期神经氨酸酶抑制剂治疗（OR 0.401，95% CI 0.127-0.878，p = 0.001）和入院时全身使用皮质类固醇（或：6.414，95%CI 1.348-30.512，p = 0.020）与流感p型IC患者的30天死亡率独立相关。淋巴细胞计数的最佳临界值为0.6 × 109/L [ROC下面积（AUROC）= 0.824，95% CI 0.744-0.887]，敏感性为97.8%，特异性为73.7%]。IC条件与流感-p患者更严重的结局相关。我们确定的死亡率预测因子可能对IC患者中流感-p的管理有价值。在线版本包含补充材料，可通过10.1186/s12941-021-00462-7获得。
To explore disease severity and risk factors for 30-day mortality of adult immunocompromised (IC) patients hospitalized with influenza-related pneumonia (Flu-p). A total of 122 IC and 1191 immunocompetent patients hospitalized with Flu-p from January 2012 to December 2018 were recruited retrospectively from five teaching hospitals in China. After controlling for confounders, multivariate logistic regression analysis showed that immunosuppression was associated with increased risks for invasive ventilation [odds ratio: (OR) 2.475, 95% confidence interval (CI): 1.511–4.053, p < 0.001], admittance to the intensive care unit (OR: 3.247, 95% CI 2.064–5.106, p < 0.001), and 30-day mortality (OR: 3.206, 95% CI 1.926–5.335, p < 0.001) in patients with Flu-p. Another multivariate logistic regression model revealed that baseline lymphocyte counts (OR: 0.993, 95% CI 0.990–0.996, p < 0.001), coinfection (OR: 5.450, 95% CI 1.638–18.167, p = 0.006), early neuraminidase inhibitor therapy (OR 0.401, 95% CI 0.127–0.878, p = 0.001), and systemic corticosteroid use at admission (OR: 6.414, 95% CI 1.348–30.512, p = 0.020) were independently related to 30-day mortality in IC patients with Flu-p. Based on analysis of the receiver operating characteristic curve (ROC), the optimal cutoff for lymphocyte counts was 0.6 × 109/L [area under the ROC (AUROC) = 0.824, 95% CI 0.744—0.887], sensitivity: 97.8%, specificity: 73.7%]. IC conditions are associated with more severe outcomes in patients with Flu-p. The predictors for mortality that we identified may be valuable for the management of Flu-p among IC patients. The online version contains supplementary material available at 10.1186/s12941-021-00462-7.
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影响因子：
4.4
作者：
Muthuri SG;Venkatesan S;Myles PR;Leonardi-Bee J;Lim WS;Al Mamun A;Anovadiya AP;Araújo WN;Azziz-Baumgartner E;Báez C;Bantar C;Barhoush MM;Bassetti M;Beovic B;Bingisser R;Bonmarin I;Borja-Aburto VH;Cao B;Carratala J;Cuezzo MR;Denholm JT;Dominguez SR;Duarte PA;Dubnov-Raz G;Echavarria M;Fanella S;Fraser J;Gao Z;Gérardin P;Giannella M;Gubbels S;Herberg J;Higuera Iglesias AL;Hoeger PH;Hoffmann M;Hu X;Islam QT;Jiménez MF;Kandeel A;Keijzers G;Khalili H;Khandaker G;Knight M;Kusznierz G;Kuzman I;Kwan AM;Lahlou Amine I;Langenegger E;Lankarani KB;Leo YS;Linko R;Liu P;Madanat F;Manabe T;Mayo-Montero E;McGeer A;Memish ZA;Metan G;Mikić D;Mohn KG;Moradi A;Nymadawa P;Ozbay B;Ozkan M;Parekh D;Paul M;Poeppl W;Polack FP;Rath BA;Rodríguez AH;Siqueira MM;Skręt-Magierło J;Talarek E;Tang JW;Torres A;Törün SH;Tran D;Uyeki TM;van Zwol A;Vaudry W;Velyvyte D;Vidmar T;Zarogoulidis P;PRIDE Consortium Investigators;Nguyen-Van-Tam JS
通讯作者：
Nguyen-Van-Tam JS
影响因子：
4.4
作者：
Boonnak, Kobporn;Vogel, Leatrice;Subbarao, Kanta
通讯作者：
Subbarao, Kanta
预测病毒性肺炎患者死亡风险的临床特征：MuLBSTA 评分
影响因子：
5.2
作者：
Guo, Lingxi;Wei, Dong;Qu, Jieming
通讯作者：
Qu, Jieming
DOI：
10.1016/j.eimc.2012.02.007
发表时间：
2012-12-01
影响因子：
2.5
作者：
Lopez-Aldeguer, Jose;Iribarren, Jose A.;Lozano, Fernando
通讯作者：
Lozano, Fernando
影响因子：
11.8
作者：
Katzen, Jeremy;Kohn, Rachel;Ison, Michael G.
通讯作者：
Ison, Michael G.