Insights Into Type I and III Interferons in Asthma and Exacerbations.
Insights Into Type I and III Interferons in Asthma and Exacerbations.
复制标题
DOI：
10.3389/fimmu.2020.574027
复制
发表时间：
2020
影响因子：
7.3
通讯作者：
Manni ML
中科院分区：
文献类型：
--
作者：
Rich HE;Antos D;Melton NR;Alcorn JF;Manni ML
哮喘是一种高度流行的慢性呼吸道疾病，每年影响全球数百万人，并导致数千人死亡。哮喘患者表现出不同的表型，具有不同的遗传成分、环境原因和免疫病理特征，通过将临床特征、类固醇反应和分子通路联系起来，广泛地将哮喘患者分为2型-高或2型-低(非2型)内型。不管哮喘的严重程度和适当的疾病管理，患者可能会经历症状的急性加重和疾病控制的丧失，这通常是由呼吸道感染引发的。干扰素家族是一组细胞因子，在预防和加重包括哮喘在内的各种感染和病理过程中发挥核心作用。尤其是I型和III型干扰素在宿主免疫系统中发挥着不可或缺的作用，以抵御病原体，这似乎在儿童和成人哮喘患者中都发生了变化。干扰素的产生受损使哮喘患者更容易受到感染和2型免疫失控，促进呼吸道高反应性(AHR)和炎症，从而导致哮喘恶化。然而，并不是所有的哮喘患者都存在干扰素缺乏，干扰素表达的改变可能与2型免疫无关。在这篇综述中，我们讨论了I型和III型干扰素与哮喘之间的联系，包括在病毒感染、混合感染和细菌/真菌感染期间。我们还重点介绍了几项研究，这些研究考察了I型和III型干扰素作为哮喘相关治疗的潜在作用。
Asthma is a highly prevalent, chronic respiratory disease that impacts millions of people worldwide and causes thousands of deaths every year. Asthmatics display different phenotypes with distinct genetic components, environmental causes, and immunopathologic signatures, and are broadly characterized into type 2-high or type 2-low (non-type 2) endotypes by linking clinical characteristics, steroid responsiveness, and molecular pathways. Regardless of asthma severity and adequate disease management, patients may experience acute exacerbations of symptoms and a loss of disease control, often triggered by respiratory infections. The interferon (IFN) family represents a group of cytokines that play a central role in the protection against and exacerbation of various infections and pathologies, including asthma. Type I and III IFNs in particular play an indispensable role in the host immune system to fight off pathogens, which seems to be altered in both pediatric and adult asthmatics. Impaired IFN production leaves asthmatics susceptible to infection and with uncontrolled type 2 immunity, promotes airway hyperresponsiveness (AHR), and inflammation which can lead to asthma exacerbations. However, IFN deficiency is not observed in all asthmatics, and alterations in IFN expression may be independent of type 2 immunity. In this review, we discuss the link between type I and III IFNs and asthma both in general and in specific contexts, including during viral infection, co-infection, and bacterial/fungal infection. We also highlight several studies which examine the potential role for type I and III IFNs as asthma-related therapies.
登录
查看更多内容
影响因子：
6.1
作者：
da Silva, J.;Hilzendeger, C.;Louis, R.
通讯作者：
Louis, R.
人元病毒糖蛋白G抑制先天免疫反应。
影响因子：
6.7
作者：
Bao, Xiaoyong;Liu, Tianshuang;Shan, Yichu;Li, Kui;Garofalo, Roberto P.;Casola, Antonella
通讯作者：
Casola, Antonella
DOI：
10.1164/rccm.201312-2235oc
发表时间：
2014-07-15
影响因子：
24.7
作者：
Djukanovic, Ratko;Harrison, Tim;Monk, Phillip
通讯作者：
Monk, Phillip
DOI：
10.1038/mtm.2014.5
发表时间：
2014
期刊：
Molecular therapy. Methods & clinical development
影响因子：
--
作者：
通讯作者：
--
影响因子：
158.5
作者：
Bisgaard, Hans;Hermansen, Mette Northman;Pipper, Christian Bressen
通讯作者：
Pipper, Christian Bressen