Perspectives of people living with HIV and health workers about a point-of-care adherence assay: a qualitative study on acceptability.
Perspectives of people living with HIV and health workers about a point-of-care adherence assay: a qualitative study on acceptability.
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DOI：
10.1080/09540121.2023.2174928
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发表时间：
2023-10
影响因子：
1.7
通讯作者：
Hoddinott, Graeme
中科院分区：
文献类型：
--
作者：
Mcinziba, Abenathi;Wademan, Dillon;Viljoen, Lario;Myburgh, Hanlie;Jennings, Lauren;Decloedt, Eric;Orrell, Catherine;van Zyl, Gert;van Schalkwyk, Marije;Gandhi, Monica;Hoddinott, Graeme
目前的抗逆转录病毒治疗(ART)依从性监测是以患者自我报告的依从性行为为前提的(容易回忆错误)，并通过血液病毒载量测量(这可能会推迟结果)进行验证。一种新开发的尿替诺福韦快速测定法(UTRA)可以在护理现场评估尿中的替诺福韦，是一种测试艾滋病毒携带者(PLHIV)依从性水平并立即做出反应的新工具。我们探讨了PLHIV和卫生工作者对将UTRA整合到常规医疗中以获得依从性支持的初步看法。我们在南非开普敦的一家初级保健保健机构对PLHIV(n=25)和卫生工作者(n=5)进行了一系列一次性的深入定性访谈。数据分析包括对关键紧急主题的描述性总结，并附有说明性案例。我们采用演绎的、以结果为导向的分析方法，利用由提供的执行成果框架对摘要进行分析。指导我们评估的三个相关概念是：可接受性、适当性和可行性。我们发现许多PLHIV和卫生工作者参与者对UTRA有积极的看法。许多艾滋病毒感染者报告说，UTRA提供的直接结果使他们能够与卫生工作者就如何实时解决遵守问题进行建设性的讨论。很少有PLHIV报告担心饮酒可能会影响他们的UTRA结果。许多卫生工作者报告说，UTRA可以帮助他们识别有治疗失败风险的患者，并通过咨询立即进行干预，但一些人转述说，如果他们的繁忙设施能够增加更多的工作人员，他们将支持UTRA的实施。总体而言，这些发现表明，研究中的许多PLHIV和卫生工作者普遍认为UTRA是可以接受和可操作的。
Current antiretroviral therapy (ART) adherence monitoring is premised on patients’ self-reported adherence behaviour (prone to recall error) and verified by blood viral load measurement (which can delay results). A newly developed Urine Tenofovir Rapid Assay (UTRA) assesses tenofovir in urine at point-of-care and is a novel tool to test and immediately respond to adherence levels of people living with HIV (PLHIV). We explored PLHIV and health workers’ initial perceptions about integrating the UTRA into routine medical care for adherence support. We conducted a series of once-off in-depth qualitative interviews with PLHIV (n=25) and health workers (n=5) at a primary care health facility in Cape Town, South Africa. Data analysis involved descriptive summaries of key emergent themes with illustrative case examples. We applied a deductive, outcomes-driven analytic approach to the summaries using the Implementation Outcomes Framework proffered by. The three relevant concepts from this framework that guided our evaluation were: acceptability, appropriateness, and feasibility. We found positive perceptions about the UTRA from many PLHIV and health worker participants. Many PLHIV reported that the immediate results offered by the UTRA could enable them to have constructive discussions with health workers on how to resolve adherence challenges in real-time. Few PLHIV reported concerns that drinking alcohol could affect their UTRA results. Many health workers reported that the UTRA could help them identify patients at risk of treatment failure and immediately intervene through counselling, though some relayed that they would support UTRA’s implementation if more staff members could be added in their busy facility. Overall, these findings show that the UTRA was widely perceived to be acceptable and actionable by many PLHIV and health workers in the study.
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DOI：
10.1097/qai.0000000000002032
发表时间：
2019-07-01
影响因子：
3.6
作者：
Phillips, Tamsin K.;Sinxadi, Phumla;Maartens, Gary
通讯作者：
Maartens, Gary
影响因子：
3.8
作者：
Spinelli, Matthew A.;Glidden, David, V;Gandhi, Monica
通讯作者：
Gandhi, Monica
影响因子：
1.7
作者：
Kaplan, R;Orrell, C;Wood, R
通讯作者：
Wood, R
DOI：
10.1080/09540121.2018.1556381
发表时间：
2019-06-03
影响因子：
1.7
作者：
Campbell，Jeffrey I.;Musiimenta，Angella;Eyal，Nir
通讯作者：
Eyal，Nir
影响因子：
3.7
作者：
Meyer-Rath G;Johnson LF;Pillay Y;Blecher M;Brennan AT;Long L;Moultrie H;Sanne I;Fox MP;Rosen S
通讯作者：
Rosen S