Catheter-based ultrasound hyperthermia with HDR brachytherapy for treatment of locally advanced cancer of the prostate and cervix.
Catheter-based ultrasound hyperthermia with HDR brachytherapy for treatment of locally advanced cancer of the prostate and cervix.
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DOI：
10.1117/12.876401
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发表时间：
2011-02-22
期刊：
影响因子：
--
通讯作者：
Hsu IC
中科院分区：
文献类型：
--
作者：
Diederich CJ;Wootton J;Prakash P;Salgaonkar V;Juang T;Scott S;Chen X;Cunha A;Pouliot J;Hsu IC
已经开发了一种临床治疗传输平台，并正在进行临床试点研究，以提供基于导管的超声波喷射器与高剂量率(HDR)近距离放射治疗相结合的3D受控热疗。与其他热疗技术相比，基于导管的超声照射器能够在设备的角度和长度上对加热进行3D空间控制，并增强了加热的径向穿透能力。组织间和腔内超声设备已经被专门开发出来，用于在宫颈和前列腺癌的放射治疗期间在HDR近距离放射治疗植入物中应用热疗。导管为基础的超声结合HDR近距离放射治疗局部晚期前列腺癌和宫颈癌的初步研究已经启动，并报告了性能和加热分布的初步结果。治疗传输平台由一个32通道射频放大器和一个48通道热电偶监测系统组成。控制软件可以在过程中根据需要监控和调节每个变送器部分的频率和功率。间质敷贴器由长度为2~4 cm×180°和3~4 cm×360°的多个换能器组成。将加热模式插入特定放置的13g植入导管。该腔内置入器由2-3个换能器×双180或360°扇区组成，可插入宫颈内径6 mm的塑料串联导管内。基于3D温度的治疗计划和优化与基于HDR优化的计划相吻合，以最佳地配置和定位导管内的敷贴器，并确定每个换能器部分的最佳基本功率水平。到目前为止，我们已经治疗了8个宫颈植入物和6个前列腺植入物。100%的治疗达到了持续60分钟的目标，所有病例的治疗温度都达到了。报道了热疗靶区(HTV)和临床靶区(CTV)内的热剂量学。基于导管的超声热疗和HDR似乎是可行的，因为治疗温度覆盖了前列腺或宫颈内的目标体积，而保留了周围更敏感的区域。(NIHR01CA122276)。
A clinical treatment delivery platform has been developed and is being evaluated in a clinical pilot study for providing 3D controlled hyperthermia with catheter-based ultrasound applicators in conjunction with high dose rate (HDR) brachytherapy. Catheter-based ultrasound applicators are capable of 3D spatial control of heating in both angle and length of the devices, with enhanced radial penetration of heating compared to other hyperthermia technologies. Interstitial and endocavity ultrasound devices have been developed specifically for applying hyperthermia within HDR brachytherapy implants during radiation therapy in the treatment of cervix and prostate. A pilot study of the combination of catheter based ultrasound with HDR brachytherapy for locally advanced prostate and cervical cancer has been initiated, and preliminary results of the performance and heating distributions are reported herein. The treatment delivery platform consists of a 32 channel RF amplifier and a 48 channel thermocouple monitoring system. Controlling software can monitor and regulate frequency and power to each transducer section as required during the procedure. Interstitial applicators consist of multiple transducer sections of 2–4 cm length × 180 deg and 3–4 cm × 360 deg. heating patterns to be inserted in specific placed 13g implant catheters. The endocavity device, designed to be inserted within a 6 mm OD plastic tandem catheter within the cervix, consists of 2–3 transducers × dual 180 or 360 deg sectors. 3D temperature based treatment planning and optimization is dovetailed to the HDR optimization based planning to best configure and position the applicators within the catheters, and to determine optimal base power levels to each transducer section. To date we have treated eight cervix implants and six prostate implants. 100 % of treatments achieved a goal of >60 min duration, with therapeutic temperatures achieved in all cases. Thermal dosimetry within the hyperthermia target volume (HTV) and clinical target volume (CTV) are reported. Catheter-based ultrasound hyperthermia with HDR appears feasible with therapeutic temperature coverage of the target volume within the prostate or cervix while sparing surrounding more sensitive regions. (NIHR01CA122276).
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影响因子：
3.1
作者：
Chen, Xin;Diederich, Chris J.;Hsu, I-Chow
通讯作者：
Hsu, I-Chow
影响因子：
3.8
作者：
Nau, WH;Diederich, CJ;Burdette, EC
通讯作者：
Burdette, EC
影响因子：
3.1
作者：
Diederich, CJ
通讯作者：
Diederich, CJ
DOI：
10.1109/58.542046
发表时间：
1996-11-01
影响因子：
3.6
作者：
Diederich, CJ;Burdette, EC
通讯作者：
Burdette, EC
影响因子：
3.8
作者：
Diederich, CJ;Stafford, RJ;Hazle, JD
通讯作者：
Hazle, JD