Angiopoietin-like protein 2 and risk of type 2 diabetes in a general Japanese population: the Hisayama study.
Angiopoietin-like protein 2 and risk of type 2 diabetes in a general Japanese population: the Hisayama study.
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DOI：
10.2337/dc12-0166
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发表时间：
2013-01
期刊：
影响因子：
16.2
通讯作者：
Kiyohara Y
中科院分区：
文献类型：
--
作者：
Doi Y;Ninomiya T;Hirakawa Y;Takahashi O;Mukai N;Hata J;Iwase M;Kitazono T;Oike Y;Kiyohara Y
首次研究新型炎症细胞因子血管生成素样蛋白（ANGPTL）2与2型糖尿病（T2 DM）发生之间的关系。共有2，164名年龄在40至79岁之间的日本社区居民接受了为期7年的随访。基线时血清ANGPTL 2水平分为四分位数类别：<2.15、2.16-2.71、2.72-3.40和≥3.41 ng/mL。在随访期间，221名参与者发展为T2 DM。在多变量分析中，调整综合风险因素和高敏C反应蛋白（hs-CRP）水平后，ANGPTL 2最高四分位数的T2 DM发生风险显著高于最低四分位数（风险比，1.80; 95%CI，1.14-2.85; P = 0.01）。在一般人群中，血清ANGPTL 2水平升高与T2 DM的发生呈正相关，与其他风险因素（包括hs-CRP水平）无关。
To examine, for the first time, the association between a novel inflammatory cytokine, angiopoietin-like protein (ANGPTL) 2, and the development of type 2 diabetes (T2DM). A total of 2,164 community-dwelling Japanese individuals aged 40 to 79 years without diabetes were followed up for 7 years. Serum ANGPTL2 levels were divided into quartile categories at baseline: <2.15, 2.16–2.71, 2.72–3.40, and ≥3.41 ng/mL. During follow-up, 221 participants developed T2DM. In multivariate analyses, after adjusting for comprehensive risk factors and high-sensitivity C-reactive protein (hs-CRP) levels, the risk of developing T2DM was significantly higher in the highest ANGPTL2 quartile than in the lowest quartile (hazard ratio, 1.80; 95% CI, 1.14–2.85; P = 0.01). Elevated serum ANGPTL2 levels were positively associated with the development of T2DM in a general population, independent of other risk factors including hs-CRP levels.
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