The Emerging, Multifaceted Role of WTAP in Cancer and Cancer Therapeutics.
The Emerging, Multifaceted Role of WTAP in Cancer and Cancer Therapeutics.
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DOI：
10.3390/cancers15113053
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发表时间：
2023-06-04
期刊：
影响因子：
5.2
通讯作者：
Peng, Chuanhui
中科院分区：
文献类型：
--
作者：
Ju, Guomin;Lei, Jiangchu;Cai, Shuqi;Liu, Siyuan;Yin, Xinjia;Peng, Chuanhui
N6-甲基腺苷（m6 A）修饰是真核生物中最常见和最保守的RNA修饰之一。m6 A在RNA上的沉积通过甲基转移酶进行。WT 1相关蛋白（WTAP）作为甲基转移酶的调节亚基，近年来逐渐受到关注。已经发现WTAP在大量癌症中异常表达，并影响癌症进展和预后。本文就WTAP在肿瘤发生发展中的作用提出新的观点，总结WTAP在肿瘤中的功能分类，并展望其潜在的治疗前景。癌症是一种严重和持久的疾病，其发病率和死亡人数都以惊人的速度增长。N6-甲基腺苷（m6 A）是真核生物中最普遍的mRNA修饰，由甲基转移酶催化，并对癌症进展的各个方面产生重大影响。WT 1相关蛋白（WTAP）是m6 A甲基转移酶复合物的重要组成部分，催化RNA上的m6 A甲基化。它已被证明参与许多细胞病理生理过程，包括X染色体失活，细胞增殖，细胞周期调控和选择性剪接。更好地了解WTAP在癌症中的作用可能使其成为早期诊断和预后的可靠因素，以及癌症治疗的关键治疗靶点。研究发现WTAP与肿瘤细胞周期调控、代谢调控、自噬、肿瘤免疫、铁凋亡、上皮间质转化（EMT）、耐药性等密切相关。本文就WTAP在肿瘤中的生物学功能及其在临床诊断和治疗中的应用前景作一综述。
N6-methyladenosine (m6A) modification is among the most common and conservative RNA modifications in eukaryotes. The deposition of m6A on RNA is carried out by methyltransferases. As a regulatory subunit of methyltransferase, WT1-associated protein (WTAP) has gradually received attention in recent years. WTAP has been found to be expressed abnormally in a large number of cancers and affects cancer progression and prognosis. In this review, we propose a new perspective on the impact of WTAP on the occurrence and development of cancer, summarize the functional classification of WTAP in cancer, and envision potential therapeutic prospects. Cancer is a grave and persistent illness, with the rates of both its occurrence and death toll increasing at an alarming pace. N6-methyladenosine (m6A), the most prevalent mRNA modification in eukaryotic organisms, is catalyzed by methyltransferases and has a significant impact on various aspects of cancer progression. WT1-associated protein (WTAP) is a crucial component of the m6A methyltransferase complex, catalyzing m6A methylation on RNA. It has been demonstrated to participate in numerous cellular pathophysiological processes, including X chromosome inactivation, cell proliferation, cell cycle regulation, and alternative splicing. A better understanding of the role of WTAP in cancer may render it a reliable factor for early diagnosis and prognosis, as well as a key therapeutic target for cancer treatment. It has been found that WTAP is closely related to tumor cell cycle regulation, metabolic regulation, autophagy, tumor immunity, ferroptosis, epithelial mesenchymal transformation (EMT), and drug resistance. In this review, we will focus on the latest advances in the biological functions of WTAP in cancer, and explore the prospects of its application in clinical diagnosis and therapy.
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影响因子：
5.5
作者：
通讯作者：
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影响因子：
4
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
通讯作者：
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影响因子：
9
作者：
Chen, Shijie;Li, Yuezhan;Li, Jinsong
通讯作者：
Li, Jinsong