Respiratory syncytial virus (RSV) and its propensity for causing bronchiolitis.
Respiratory syncytial virus (RSV) and its propensity for causing bronchiolitis.
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DOI：
10.1002/path.4462
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发表时间：
2015-01
期刊：
影响因子：
--
通讯作者：
DeVincenzo JP
中科院分区：
文献类型：
--
作者：
Pickles RJ;DeVincenzo JP
婴儿和幼儿急性发作的喘息和减少呼吸气流往往被诊断为阻塞和炎症的小细支气管气道，即细支气管炎。引起幼儿细支气管炎的最常见病原体是呼吸道病毒，在常见的呼吸道病毒中，呼吸道合胞病毒（RSV）具有引起细支气管炎的倾向。事实上，RSV细支气管炎仍然是以前健康的婴儿住院的主要原因。为什么RSV感染是毛细支气管炎的主要原因是本次审查的主题。通过回顾人类和相关动物模型中RSV细支气管炎的现有组织病理学，我们确定了远端气道RSV感染的标志性特征，并将注意力集中在细支气管中发生的柱状细胞病理学的后果上，这直接影响细支气管阻塞，炎症和疾病的发展。版权所有© 2014大不列颠及爱尔兰病理学会。由John Wiley & Sons有限公司出版
Infants and young children with acute onset of wheezing and reduced respiratory airflows are often diagnosed with obstruction and inflammation of the small bronchiolar airways, ie bronchiolitis. The most common aetological agents causing bronchiolitis in young children are the respiratory viruses, and of the commonly encountered respiratory viruses, respiratory syncytial virus (RSV) has a propensity for causing bronchiolitis. Indeed, RSV bronchiolitis remains the major reason why previously healthy infants are admitted to hospital. Why RSV infection is such a predominant cause of bronchiolitis is the subject of this review. By reviewing the available histopathology of RSV bronchiolitis, both in humans and relevant animal models, we identify hallmark features of RSV infection of the distal airways and focus attention on the consequences of columnar cell cytopathology occurring in the bronchioles, which directly impacts the development of bronchiolar obstruction, inflammation and disease. Copyright © 2014 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
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影响因子：
--
作者：
CHANOCK, R;FINBERG, L
通讯作者：
FINBERG, L
影响因子：
168.9
作者：
Lozano, Rafael;Naghavi, Mohsen;Murray, Christopher J. L.
通讯作者：
Murray, Christopher J. L.
DOI：
10.1056/nejmoa0804877
发表时间：
2009-02-05
期刊：
The New England journal of medicine
影响因子：
--
作者：
Hall CB;Weinberg GA;Iwane MK;Blumkin AK;Edwards KM;Staat MA;Auinger P;Griffin MR;Poehling KA;Erdman D;Grijalva CG;Zhu Y;Szilagyi P
通讯作者：
Szilagyi P
DOI：
10.1007/s10096-011-1529-y
发表时间：
2012-08-01
影响因子：
4.5
作者：
Hervas, D.;Reina, J.;Hervas, J. A.
通讯作者：
Hervas, J. A.
影响因子：
2.4
作者：
BRYSON, DG;MCCONNELL, S;MCNULTY, MS
通讯作者：
MCNULTY, MS