Peripheral nerve injury up-regulates expression of interactor protein for cytohesin exchange factor 1 (IPCEF1) mRNA in rat dorsal root ganglion.
Peripheral nerve injury up-regulates expression of interactor protein for cytohesin exchange factor 1 (IPCEF1) mRNA in rat dorsal root ganglion.
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DOI：
10.1007/s00210-009-0451-7
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发表时间：
2009-11
影响因子：
3.6
通讯作者：
Tao, Yuan-Xiang
中科院分区：
文献类型：
--
作者：
Guan, Xiaowei;Zhu, Xuguang;Tao, Yuan-Xiang
IPCEF1 （interinteraction protein for cytohesin exchange factors 1）是最近发现的一种结合胞嘧啶2的蛋白，可能通过增强胞嘧啶2的活性参与细胞膜受体的转运。然而，IPCEF1在体内是否参与这一过程尚不清楚。在此，我们报道IPCEF1 mRNA在成年大鼠背根神经节（DRGs）中表达。此外，第五脊神经结扎和横断或坐骨神经横断引起的周围神经损伤显著上调了受损DRGs中IPCEF1 mRNA的表达。由于周围神经损伤导致受损DRG中膜受体转运的改变，IPCEF1 mRNA表达与受损DRG中神经损伤输入的相关性表明，IPCEF1可能参与了神经性疼痛条件下神经损伤诱导DRG中膜受体转运的机制。
Interaction protein for cytohesin exchange factors 1 (IPCEF1) is a recently identified protein that binds to cytohesin 2 and might participate in membrane receptor trafficking by enhancing the activity of cytohesin 2 in cultured cells. However, whether IPCEF1 is involved in this process in vivo is unknown. Here, we report that IPCEF1 mRNA is expressed in the dorsal root ganglions (DRGs) of adult rats. Moreover, peripheral nerve injury induced by fifth spinal nerve ligation and transection or sciatic nerve transection significantly up-regulated expression of IPCEF1 mRNA in the injured DRGs. Because peripheral nerve injury leads to changes in membrane receptor trafficking in the injured DRG, the correlation of IPCEF1 mRNA expression with nerve injury input in the injured DRG suggests that IPCEF1 might participate in the mechanisms that underlie nerve injury-induced membrane receptor trafficking in the DRG under neuropathic pain conditions.
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周围神经损伤后脊髓背角突触体相关蛋白的蛋白质组。
影响因子：
3.4
作者：
Singh, Om V.;Yaster, Myron;Xu, Ji-Tian;Guan, Yun;Guan, Xiaowei;Dharmarajan, Arun M.;Raja, Srinivasa N.;Zeitlin, Pamela L.;Tao, Yuan-Xiang
通讯作者：
Tao, Yuan-Xiang
影响因子：
3.3
作者：
Guan Y;Yaster M;Raja SN;Tao YX
通讯作者：
Tao YX
影响因子：
4.8
作者：
Venkateswarlu, K
通讯作者：
Venkateswarlu, K
DOI：
10.1523/jneurosci.3474-08.2009
发表时间：
2009-02-11
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Jankowski MP;Lawson JJ;McIlwrath SL;Rau KK;Anderson CE;Albers KM;Koerber HR
通讯作者：
Koerber HR
影响因子：
7.4
作者：
Zhang, BS;Tao, F;Tao, YX
通讯作者：
Tao, YX