A Systemic Review of the Integral Role of TRPM2 in Ischemic Stroke: From Upstream Risk Factors to Ultimate Neuronal Death.
A Systemic Review of the Integral Role of TRPM2 in Ischemic Stroke: From Upstream Risk Factors to Ultimate Neuronal Death.
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作者：
Zong P;Lin Q;Feng J;Yue L
缺血性中风在世界范围内造成沉重的健康负担，每年有超过1000万新病例。尽管缺血性脑卒中的患病率和死亡率很高，但缺血性脑卒中的常见病因和缺血性脑卒中本身的潜在分子机制仍不清楚，这导致对这种毁灭性疾病的预防策略不足和治疗无效。本文综述了瞬时受体电位阳离子通道M亚家族成员2（TRPM 2），一种氧化应激激活的非选择性离子通道，在缺血性脑卒中的病因和病理过程中起着重要作用。TRPM 2可能是筛选缺血性卒中更有效的预防策略和治疗药物的一个有前途的靶点。
Ischemic stroke causes a heavy health burden worldwide, with over 10 million new cases every year. Despite the high prevalence and mortality rate of ischemic stroke, the underlying molecular mechanisms for the common etiological factors of ischemic stroke and ischemic stroke itself remain unclear, which results in insufficient preventive strategies and ineffective treatments for this devastating disease. In this review, we demonstrate that transient receptor potential cation channel, subfamily M, member 2 (TRPM2), a non-selective ion channel activated by oxidative stress, is actively involved in all the important steps in the etiology and pathology of ischemic stroke. TRPM2 could be a promising target in screening more effective prophylactic strategies and therapeutic medications for ischemic stroke.
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DOI：
10.1111/micc.12046
发表时间：
2013-05
期刊：
Microcirculation (New York, N.Y. : 1994)
影响因子：
--
作者：
Amberg GC;Navedo MF
通讯作者：
Navedo MF
影响因子：
24
作者：
Adam, Oliver;Lavall, Daniel;Laufs, Ulrich
通讯作者：
Laufs, Ulrich
影响因子：
158.5
作者：
AMARENCO, P;COHEN, A;BOUSSER, MG
通讯作者：
BOUSSER, MG
TRPM2离子通道调节幽门螺杆菌感染期间巨噬细胞极化和胃炎。
影响因子：
8
作者：
Beceiro S;Radin JN;Chatuvedi R;Piazuelo MB;Horvarth DJ;Cortado H;Gu Y;Dixon B;Gu C;Lange I;Koomoa DL;Wilson KT;Algood HM;Partida-Sánchez S
通讯作者：
Partida-Sánchez S
影响因子：
6.6
作者：
Appari M;Channon KM;McNeill E
通讯作者：
McNeill E