Genomic insights into the emergence and spread of antimicrobial-resistant bacterial pathogens.

Genomic insights into the emergence and spread of antimicrobial-resistant bacterial pathogens.
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基因组对抗菌抗菌细菌病原体的出现和传播的见解。

DOI：
10.1126/science.aar3777
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发表时间：
2018-05-18
期刊：
Science (New York, N.Y.)
影响因子：
--
通讯作者：
Holt KE
Holt KE
中科院分区：
其他
文献类型：
--
作者：
Baker S;Thomson N;Weill FX;Holt KE
来源链接：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6510332/

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全基因组测序 (WGS) 对于揭示细菌病原体抗菌素耐药性 (AMR) 的快速时间和空间演变至关重要。一些耐药病原体的传播速度已经超过了我们，医院和社区中出现了无法治愈的感染。然而，WGS 还为我们提供了足够的知识来采取对策。尽管我们无法阻止细菌的适应，但 AMR 细菌许多进化过程的可预测性为我们提供了使用新控制策略引导它们的机会。此外，通过使用全基因组测序来协调监测并对抗菌治疗的结果和抗菌素耐药性机制有更基本的了解，我们可以更有效地使用当前和未来的抗菌药物，并旨在延长其寿命。
Whole-genome sequencing (WGS) has been vital for revealing the rapid temporal and spatial evolution of antimicrobial resistance (AMR) in bacterial pathogens. Some antimicrobialresistant pathogens have outpaced us, with untreatable infections appearing in hospitals and the community. However,WGS has additionally provided us with enough knowledge to initiate countermeasures. Although we cannot stop bacterial adaptation, the predictability of many evolutionary processes in AMR bacteria offers us an opportunity to channel them using new control strategies. Furthermore, by usingWGS for coordinating surveillance and to create a more fundamental understanding of the outcome of antimicrobial treatment and AMR mechanisms, we can use current and future antimicrobials more effectively and aim to extend their longevity.
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