Molecular cloning and complete nucleotide sequence of an adult T cell leukaemia virus/human T cell leukaemia virus type I (ATLV/HTLV-I) isolate of Caribbean origin: relationship to other members of the ATLV/HTLV-I subgroup.
Molecular cloning and complete nucleotide sequence of an adult T cell leukaemia virus/human T cell leukaemia virus type I (ATLV/HTLV-I) isolate of Caribbean origin: relationship to other members of the ATLV/HTLV-I subgroup.
复制标题
加勒比起源的成人 T 细胞白血病病毒/人 T 细胞白血病病毒 I 型 (ATLV/HTLV-I) 分离株的分子克隆和完整核苷酸序列：与 ATLV/HTLV-I 亚组其他成员的关系。
DOI：
--
复制
发表时间：
1988
影响因子：
3.8
通讯作者：
Abraham Karpas
中科院分区：
文献类型：
--
作者：
Karim T. A. Malik;Jos Even;Abraham Karpas
我们报道了第一个成人T细胞白血病病毒/人T细胞白血病病毒I型(ATLV/HTLV-I)分离株的完整核苷酸序列，该分离株来自加勒比海地区的英国患者。我们的前病毒克隆(HS-35)与其他分子克隆的序列比较显示。我们注意到加勒比分离株和日本分离株之间存在很强的序列保守性(2.3%的差异)，但来自相似地理区域的分离株之间存在较高的同源性(约1%的差异)。对ATLV/HTLV-I亚群的起源、演化和传播的意义进行了讨论。还报道了从同一基因组文库中分离的缺陷前病毒克隆的分析，并提出了在缺陷前病毒的生物发生过程中前病毒序列缺失的模式。
We report the first complete nucleotide sequence of an adult T cell leukaemia virus/human T cell leukaemia virus type I (ATLV/HTLV-I) isolate from a British patient of Caribbean origin. Sequence comparisons of our proviral clone (HS-35) with other molecular clones are shown. We note the strong sequence conservation between isolates of Caribbean and Japanese origin (2.3% divergence), but demonstrate the higher homologies existing between isolates originating from similar geographical areas (approximately 1% divergence). Implications for the origin, evolution and dissemination of the ATLV/HTLV-I subgroup are discussed. Analysis of defective proviral clones isolated from the same genomic library is also reported, and suggests a pattern of proviral sequence deletions during the biogenesis of defective proviruses.
人类T细胞白血病病毒基因表达的调节需要多个序列元件。
DOI：
10.1073/pnas.84.14.4919
发表时间：
1987
影响因子：
11.1
作者：
Rosen,CA;Park,R;Sodroski,JG;Haseltine,WA
通讯作者：
Haseltine,WA