Current ebola vaccines.
Current ebola vaccines.
复制标题
目前的埃博拉疫苗。
DOI：
10.1517/14712598.2012.685152
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发表时间：
2012-07
影响因子：
4.6
通讯作者：
Feldmann H
中科院分区：
文献类型：
--
作者：
Hoenen T;Groseth A;Feldmann H
Ebolaviruses cause severe viral hemorrhagic fever in humans and non-human primates, with case fatality rates of up to 90%. Currently, neither a specific treatment nor a vaccine licensed for use in humans is available. However, a number of vaccine candidates have been developed in the last decade that are highly protective in non-human primates, the gold standard animal model for Ebola hemorrhagic fever. This review analyzes a number of scenarios for the use of ebolavirus vaccines, discusses the requirements for ebolavirus vaccines in these scenarios, and describes current ebolavirus vaccines. Among these vaccines are recombinant Adenoviruses, recombinant Vesicular Stomatitis viruses, recombinant Human Parainfluenza viruses and virus-like particles. Interestingly, one of these vaccine platforms, based on recombinant Vesicular Stomatitis viruses, has also demonstrated post-exposure protection in non-human primates. The most pressing remaining challenge is now to move these vaccine candidates forward into human trials and towards licensure. In order to achieve this, it will be necessary to establish the mechanisms and correlates of protection for these vaccines, and to continue to demonstrate their safety, particularly in potentially immunocompromised populations. However, already now there is sufficient evidence that, from a scientific perspective, a vaccine protective against ebolaviruses is possible.
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影响因子：
3.7
作者：
Beniac DR;Melito PL;Devarennes SL;Hiebert SL;Rabb MJ;Lamboo LL;Jones SM;Booth TF
通讯作者：
Booth TF
影响因子：
7.3
作者：
BASKERVILLE, A;BOWEN, ETW;SIMPSON, DIH
通讯作者：
SIMPSON, DIH
影响因子：
5.4
作者：
Bukreyev, Alexander;Rollin, Pierre E.;Sanchez, Anthony
通讯作者：
Sanchez, Anthony
影响因子：
3.7
作者：
Bukreyev, Alexander A.;DiNapoli, Joshua M.;Collins, Peter L.
通讯作者：
Collins, Peter L.
DOI：
10.1016/s0140-6736(10)60357-1
发表时间：
2010-05-29
期刊：
Lancet (London, England)
影响因子：
--
作者：
Geisbert TW;Lee AC;Robbins M;Geisbert JB;Honko AN;Sood V;Johnson JC;de Jong S;Tavakoli I;Judge A;Hensley LE;Maclachlan I
通讯作者：
Maclachlan I