Autocrine IFN-γ promotes naive CD8 T cell differentiation and synergizes with IFN-α to stimulate strong function.
Autocrine IFN-γ promotes naive CD8 T cell differentiation and synergizes with IFN-α to stimulate strong function.
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DOI：
10.4049/jimmunol.1102727
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发表时间：
2012-07-15
期刊：
影响因子：
--
通讯作者：
Mescher MF
中科院分区：
文献类型：
--
作者：
Curtsinger JM;Agarwal P;Lins DC;Mescher MF
Autocrine IFN-γ signaling is important for CD4 differentiation to T helper 1 effector cells, but it has been unclear whether it contributes to CD8 T cell differentiation. We show here that naïve murine CD8 T cells rapidly and transiently produce low levels of IFN-γ upon stimulation with Ag and B7-1, with production peaking at about 8 hours and declining by 24 hours. The autocrine IFN-γ signals for upregulation of expression of Tbet and GrzB, and induces weak cytolytic activity and effector IFN-γ production. IFN-α acts synergistically with IFN-γ to support development of strong effector functions, while IL-12 induces high T-bet expression and strong function in the absence of IFN-γ signaling. Thus, IFN-γ is not only an important CD8 T cell effector cytokine, it is an autocrine/paracrine factor whose contributions to differentiation vary depending on whether the response is supported by IL-12 or Type I IFN.
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影响因子：
7
作者：
Curtsinger JM;Mescher MF
通讯作者：
Mescher MF
DOI：
10.1073/pnas.0902745106
发表时间：
2009-04-28
影响因子：
11.1
作者：
Ben-Sasson, Shlomo Z.;Hu-Li, Jane;Paul, William E.
通讯作者：
Paul, William E.
影响因子：
30.5
作者：
Hu, XY;Herrero, C;Ivashkiv, LB
通讯作者：
Ivashkiv, LB
影响因子：
30.5
作者：
Intlekofer, AM;Takemoto, N;Reiner, SL
通讯作者：
Reiner, SL
影响因子：
4.4
作者：
Johnson, Lisa D. S.;Jameson, Stephen C.
通讯作者：
Jameson, Stephen C.