Inspiratory muscle activity as a trigger causing the airways to open in obstructive sleep apnea.
Inspiratory muscle activity as a trigger causing the airways to open in obstructive sleep apnea.
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吸气肌活动作为触发因素，导致阻塞性睡眠呼吸暂停中气道打开。
DOI：
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发表时间：
2015
期刊：
影响因子：
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通讯作者：
A. Grassino
中科院分区：
文献类型：
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作者：
W. Vincken;C. Guilleminault;L. Silvestri;M. Cosio;A. Grassino
本报告讨论了阻塞性睡眠呼吸暂停（OSAS）期间导致气道开放的机制。在4例男性OSAS患者中，92例非快速眼动（NERM）睡眠呼吸暂停发作和37例快速眼动（REM）睡眠呼吸暂停发作在一个晚上的研究中进行了呼吸分析。计算膈肌压力时间指数（吸气时间/周期持续时间（T1/Ttot）和平均跨膜压幅的乘积），通过EEG评估睡眠阶段，并对膈肌肌电图进行频谱分析。结果发现，随着每次阻塞吸气努力，隔膜的张力时间指数（TTdi）逐渐增加，达到或略超过疲劳阈值，0.15至0.18（在NREM睡眠期间，最后一次阻塞呼吸的TTdi为0.195 +/-0.045，而在REM睡眠期间，最后一次阻塞呼吸的TTdi为0.153 +/-0.037）;在觉醒的开始和气道的开放之间也观察到密切的时间关系。我们的数据表明，气道可能会触发开放的保护反射起源于喉或吸气肌肉达到一定程度的收缩。
This report discusses mechanisms causing the airways to open during obstructive sleep apnea (OSAS). In 4 male patients with OSAS, 92 nonrapid eye movement (NERM) sleep apnea episodes and 37 rapid eye movement (REM) sleep apnea episodes were analyzed breath by breath during a one-night study. We calculated the pressure time index of the diaphragm (the product of inspiratory time/cycle duration (Tl/Ttot) and mean transdiaphragmatic pressure swing), evaluated the sleep stages via EEG, and performed frequency spectrum analysis of the EMG of the diaphragm. It was found that with each occluded inspiratory effort the tension time index of the diaphragm (TTdi) increased progressively to reach or slightly exceed the fatigue threshold, 0.15 to 0.18 (during NREM sleep the TTdi of the last occluded breath was 0.195 +/- 0.045 and during REM sleep the TTdi of the last occluded breath was 0.153 +/- 0.037); that a close time relationship was observed as well between the onset of arousal and the opening of the airways. Our data suggest that the airways may be triggered to open by a protective reflex originating in the larynx or the inspiratory muscles upon reaching a certain degree of contraction.
上气道压力变化对颏舌肌呼吸活动的影响。
DOI：
10.1152/jappl.1982.52.2.438
发表时间：
1982
期刊：
Journal of applied physiology: respiratory, environmental and exercise physiology
影响因子：
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作者：
Mathew,OP;Abu-Osba,YK;Thach,BT
通讯作者：
Thach,BT