Modeling Pharmacokinetics and Pharmacodynamics on a Mobile Device to Help Caffeine Users

Modeling Pharmacokinetics and Pharmacodynamics on a Mobile Device to Help Caffeine Users
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在移动设备上建模药代动力学和药效动力学以帮助咖啡因用户

DOI:
10.1007/978-3-642-21852-1_61
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发表时间:
2011
期刊:
Food Additives & Contaminants
影响因子:
--
通讯作者:
Kuo
Kuo
中科院分区:
--
文献类型:
--
作者:
F. Ritter;Kuo

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我们介绍了一个移动终端应用程序,它可以在iPhone、iPod Touch和iPad上直观地显示有关咖啡因的关键信息:药代动力学(药物水平的时间过程)和药效学(咖啡因水平的影响)。这个应用程序,咖啡因区,是基于现有的咖啡因生理模型,使用用户输入,包括咖啡因剂量,开始时间和消费速度。它计算用户在接下来的24小时内的咖啡因负荷,并使用折线图显示。此外,它还显示用户当前是否处于“认知警戒区”(正常人可能从咖啡因中获益最多的咖啡因范围)或“可能的睡眠区”(假定睡眠不受咖啡因水平影响的咖啡因范围)。了解咖啡因的药代动力学和药效学可以帮助使用咖啡因的人提高警觉性,包括在操作环境中。Caffeine Zone还可以帮助用户在设备不可用时创建咖啡因水平的心理模型。我们认为,这款应用程序既能教会用户复杂的咖啡因吸收/消除过程,又能帮助监控用户的日常咖啡因使用情况。该模型,与额外的验证,可以是一个系统,预测用户的认知状态,并在关键条件下提供援助的一部分。
We introduce a mobile device application that displays key information about caffeine: the pharmacokinetics (time course of drug levels) and pharmacodynamics (the effects of caffeine level) visually on the iPhone, iPod Touch, and iPad. This application, Caffeine Zone, is based on an existing model of caffeine physiology using user inputs, including caffeine dose, start time, and consumption speed. It calculates the caffeine load in a user for the next twenty-four hours and displays it using a line chart. In addition, it shows whether the user is currently in the "cognitive alert zone" (the range of caffeine where a normal person might benefit most from caffeine) or the "possible sleep zone" (the range of caffeine where sleep is presumed not affected by caffeine level.) Understanding the pharmacokinetics and pharmacodynamics of caffeine can help people using caffeine to improve alertness, including in operational environments. Caffeine Zone may also help users create a mental model of caffeine levels when the device is not available. We argue that this app will both teach users the complex absorption/elimination process of caffeine and help monitor users' daily caffeine usage. The model, with additional validation, can be part of a system that predict cognitive state of users and provide assistances in critical conditions.
DOI: --
发表时间: 1999-03
影响因子: 21.1
作者:
B. Fredholm;K. Bättig;J. Holmén;A. Nehlig;E. Zvartau
通讯作者: B. Fredholm;K. Bättig;J. Holmén;A. Nehlig;E. Zvartau
DOI: 10.1176/ajp.156.2.223
发表时间: 1999-02
期刊: The American journal of psychiatry
影响因子: --
作者:
K. Kendler;C. Prescott
通讯作者: K. Kendler;C. Prescott