Impact of smoking on cognitive decline in early old age: the Whitehall II cohort study.
Impact of smoking on cognitive decline in early old age: the Whitehall II cohort study.
复制标题
DOI：
10.1001/archgenpsychiatry.2011.2016
复制
发表时间：
2012-06
影响因子：
--
通讯作者：
Singh-Manoux, Archana
中科院分区：
文献类型：
--
作者：
Sabia, Severine;Elbaz, Alexis;Dugravot, Aline;Head, Jenny;Shipley, Martin;Hagger-Johnson, Gareth;Kivimaki, Mika;Singh-Manoux, Archana
吸烟是痴呆症的一个可能的危险因素，尽管由于吸烟者寿命较短，它对老年人口的影响可能被低估了。研究从中年到老年的过程中，吸烟史与认知能力下降之间的关系。数据来自白厅II研究中的5099名男性和2137名女性，第一次认知评估(1997-1999年)的平均年龄为56岁(范围=44-69岁)，重复时间为2002-2004年和2007-2009年。认知测试组合包括记忆、词汇、执行功能(由一项推理和两项流利性测试组成)测试，以及总结所有五项测试表现的全球认知分数。在整个研究期间对吸烟状况进行了评估。线性混合模型被用来评估吸烟史和10年认知下降之间的关联，以z分数表示。在男性中，从不吸烟的人在除词汇外的所有测试中的10年认知下降幅度都在基线标准差的四分之一到三分之一之间。与从不吸烟的男性相比，现在吸烟者的认知能力下降速度更快[全球认知能力10年下降的平均差值=−0.09(95%CI：−0.15；−0.03)和执行功能=−0.11(−0.17；−0.05)]。近期戒烟者的执行功能下降较大(−0.08(−0.14；−0.02))，而长期吸烟者的下降与从不吸烟者相似。在另外考虑到辍学和死亡的分析中，这些差异要大1.2到1.5倍。在女性中，认知能力的下降不会随着吸烟状况的变化而变化。与从不吸烟的人相比，中年男性吸烟者在全球认知和执行功能方面的认知衰退速度更快。在戒烟至少10年的戒烟者中，对认知能力下降没有不良影响。
Smoking is a possible risk factor for dementia although its impact may have been underestimated in elderly populations due to the shorter lifespan of smokers. To examine the association between smoking history and cognitive decline in the transition from midlife to old age. Data are from 5099 men and 2137 women in the Whitehall II study, mean age 56 years (range=44–69 years) at the first cognitive assessment (1997–1999), repeated over 2002–2004 and 2007–2009. The cognitive test battery was composed of tests of memory, vocabulary, executive function (composed of one reasoning and two fluency tests), and a global cognitive score summarising performance across all five tests. Smoking status was assessed over the entire study period. Linear mixed models were used to assess the association between smoking history and 10-year cognitive decline, expressed as z-scores. In men, 10-year cognitive decline in all tests except vocabulary among never smokers ranged from a quarter to a third of the baseline standard deviation. Faster cognitive decline was observed among current smokers compared to never smokers in men [mean difference in 10-year decline in global cognition=−0.09 (95%CI:−0.15;−0.03) and executive function=−0.11 (−0.17;−0.05)]. Recent ex-smokers had greater decline in executive function (−0.08 (−0.14;−0.02)) while the decline in long-term ex-smokers was similar to that among never smokers. In analyses that additionally took drop-out and death into account, these differences were 1.2 to 1.5 times larger. In women, cognitive decline did not vary as a function of smoking status. Compared to never smokers, middle-aged male smokers experienced faster cognitive decline in global cognition and executive function. In ex-smokers with at least 10-year cessation there were no adverse effects on cognitive decline.
登录
查看更多内容
影响因子：
5
作者：
Elbaz, A;Alpérovitch, A
通讯作者：
Alpérovitch, A
DOI：
10.1093/biostatistics/1.4.465
发表时间：
2000-12-01
期刊：
Biostatistics (Oxford, England)
影响因子：
--
作者：
Henderson, R;Diggle, P;Dobson, A
通讯作者：
Dobson, A
影响因子：
7.2
作者：
Collins, Nicole;Sachs-Ericsson, Natalie;Markides, Kyriakos
通讯作者：
Markides, Kyriakos
影响因子：
2
作者：
Diggle, Peter J.;Sousa, Ines;Chetwynd, Amanda G.
通讯作者：
Chetwynd, Amanda G.
影响因子：
14
作者：
Knopman, David S.;Mosley, Thomas H.;Coker, Laura H.
通讯作者：
Coker, Laura H.