Macrophage polarization and meta-inflammation.
Macrophage polarization and meta-inflammation.
复制标题
巨噬细胞极化和元炎。
DOI：
10.1016/j.trsl.2017.10.004
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发表时间：
2018-01
期刊：
影响因子：
--
通讯作者：
Zhou B
中科院分区：
文献类型：
--
作者：
Li C;Xu MM;Wang K;Adler AJ;Vella AT;Zhou B
慢性营养过剩和肥胖会导致全身低度炎症。这种慢性炎症状态被称为“后炎症”，由位于结肠、肝脏、肌肉和脂肪组织内的巨噬细胞介导。巨噬细胞是免疫活动和体内平衡的前哨协调者，它根据时间和环境线索采取可变的激活状态。后炎症在表型上扭曲这些极化状态，并与许多代谢紊乱有关。在过去的十年中，已经揭示了几种关键的巨噬细胞极化调节因子，包括信号转导和转录激活因子（STAT）家族、过氧化物酶体增殖物激活受体γ（PPARγ）、CCAAT增强子结合蛋白（C/EBP）家族和干扰素调节因子（IRF）。最近的研究还表明，microRNA（miRNAs）和长链非编码RNA（lncRNA）影响巨噬细胞极化。炎症后巨噬细胞极化的致病性改变受细胞外和细胞内信号的调节，导致不同的分泌组特征。炎症改变的巨噬细胞极化与胰岛素不敏感性、动脉粥样硬化、炎症性肠病、癌症和自身免疫有关。因此，对巨噬细胞极化偏斜的进一步机制探索有望对改善全球健康产生深远影响。
Chronic over-nutrition and obesity induces low-grade inflammation throughout the body. Termed “metainflammation,” this chronic state of inflammation is mediated by macrophages located within the colon, liver, muscle and adipose tissue. A sentinel orchestrator of immune activity and homeostasis, macrophages adopt variable states of activation as a function of time and environmental cues. Metainflammation phenotypically skews these polarization states and has been linked to numerous metabolic disorders. The past decade has revealed several key regulators of macrophage polarization, including the Signal Transducer and Activator of Transcription (STAT) family, the peroxisome proliferator-activated receptor gamma (PPARγ), the CCAAT-enhancer-binding proteins (C/EBP) family and the Interferon regulatory factors (IRFs). Recent studies have also suggested that microRNAs (miRNAs) and long noncoding RNA (lncRNA) influence macrophage polarization. The pathogenic alteration of macrophage polarization in metainflammation is regulated by both extracellular and intracellular cues, resulting in distinct secretome profiles. Metainflammation-altered macrophage polarization has been linked to insulin insensitivity, atherosclerosis, inflammatory bowel disease, cancer and autoimmunity. Thus, further mechanistic exploration into the skewing of macrophage polarization promises to have profound impacts on improving global health.
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影响因子：
82.9
作者：
Arkan, MC;Hevener, AL;Karin, M
通讯作者：
Karin, M
影响因子：
7.7
作者：
Cani, Patrice D.;Amar, Jacques;Burcelin, Remy
通讯作者：
Burcelin, Remy
影响因子：
3.4
作者：
Antonio Reales-Calderon, Jose;Aguilera-Montilla, Noemi;Gil, Concha
通讯作者：
Gil, Concha
DOI：
10.4049/jimmunol.1202496
发表时间：
2013-06-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Banerjee S;Xie N;Cui H;Tan Z;Yang S;Icyuz M;Abraham E;Liu G
通讯作者：
Liu G
影响因子：
11.1
作者：
Amar, Jacques;Chabo, Chantal;Waget, Aurelie;Klopp, Pascale;Vachoux, Christelle;Bermudez-Humaran, Luis G.;Smirnova, Natalia;Berge, Mathieu;Sulpice, Thierry;Lahtinen, Sampo;Ouwehand, Arthur;Langella, Philippe;Rautonen, Nina;Sansonetti, Philippe J.;Burcelin, Remy
通讯作者：
Burcelin, Remy