Topical application of entry inhibitors as "virustats" to prevent sexual transmission of HIV infection.
Topical application of entry inhibitors as "virustats" to prevent sexual transmission of HIV infection.
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DOI：
10.1186/1742-4690-5-116
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发表时间：
2008-12-18
期刊：
影响因子：
3.3
通讯作者：
Sieg SF
中科院分区：
文献类型：
--
作者：
Lederman MM;Jump R;Pilch-Cooper HA;Root M;Sieg SF
随着艾滋病流行病的持续蔓延和在不久的将来研制有效疫苗的希望渺茫，制定预防艾滋病毒感染的局部战略的工作日益重要。也就是说，大规模“杀微生物剂”试验的跟踪记录令人失望，非特异性抑制剂未能保护妇女免受感染，甚至增加了艾滋病毒的感染。直接靶向病毒进入细胞所需元素的新策略在非人灵长类HIV传播模型中显示出了希望，由于这些药物尚未在HIV流行率最高的地区广泛引入，因此它们对预防特别有吸引力。我们在这里审查的药物，可以阻止艾滋病毒细胞的进入，并显示出作为局部战略或“病毒抑制剂”，以防止艾滋病毒感染的粘膜传播的承诺
With the continuing march of the AIDS epidemic and little hope for an effective vaccine in the near future, work to develop a topical strategy to prevent HIV infection is increasingly important. This stated, the track record of large scale "microbicide" trials has been disappointing with nonspecific inhibitors either failing to protect women from infection or even increasing HIV acquisition. Newer strategies that target directly the elements needed for viral entry into cells have shown promise in non-human primate models of HIV transmission and as these agents have not yet been broadly introduced in regions of highest HIV prevalence, they are particularly attractive for prophylaxis. We review here the agents that can block HIV cellular entry and that show promise as topical strategies or "virustats" to prevent mucosal transmission of HIV infection
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