Clinical landscape of cancer metastases.
Clinical landscape of cancer metastases.
复制标题
DOI：
10.1002/cam4.1697
复制
发表时间：
2018-11
期刊：
影响因子：
4
通讯作者：
Hemminki K
中科院分区：
文献类型：
--
作者：
Riihimäki M;Thomsen H;Sundquist K;Sundquist J;Hemminki K
由于癌症登记处很少记录转移，因此缺乏基于人群的转移模式数据。本研究采用了一种新的基于人群的方法来识别转移，并描述了从14种常见原发癌症到12个特定转移部位的转移途径。从瑞典癌症登记处共确定了179 581例转移性癌症患者，并使用死亡原因登记册和国家患者登记册确定了转移部位。转移扩散的模式被描述为跨年龄和性别。在男性中，结直肠癌是肺、腹膜和肝转移的主要来源。肺癌是胸膜和神经系统转移的主要来源。前列腺癌以骨转移为主，但对其他转移部位的影响较小。在女性中，乳腺癌是大多数转移部位的主要来源，腹膜除外，主要是卵巢转移。作为其他例外，对于神经系统转移，肺癌是转移的起源，比乳腺癌更频繁，对于肝转移，结直肠癌是主要的起源，而不是乳腺癌。目前的成就是首次在全国范围内对癌症转移的临床情况进行描述，旨在为临床医生和研究人员提供可靠的信息来源。
Population‐based data on metastatic patterns are lacking because cancer registries seldom record metastases. This study uses a novel population‐based approach to identify metastases and describes metastatic pathways from 14 common primary cancers to 12 specific metastatic sites. A total of 179 581 patients with metastatic cancer were identified from the Swedish Cancer Registry and metastatic sites were identified using the Cause of Death Register and the National Patient Register. Patterns of metastatic spread were described across age and sex. In men, colorectal cancer was the main source of lung, peritoneal, and liver metastases. Lung cancer was the main origin of pleural and nervous system metastases. Prostate cancer dominated bone metastases but had minor contribution to other metastatic sites. Among women, breast cancer was the dominant origin of most metastatic sites, with the exception of peritoneum which was ruled by metastases from the ovary. As other exceptions, for nervous system metastases, lung cancer was the origin of metastases somewhat more frequently than breast cancer and for liver metastases, colorectal cancer was the main origin instead of breast cancer. The present achievement was to implement the first nationwide description of clinical landscape of cancer metastases, with an aim to serve as a reliable source for clinicians and researchers.
登录
查看更多内容
影响因子：
78.5
作者：
Collado, Manuel;Serrano, Manuel
通讯作者：
Serrano, Manuel
影响因子：
--
作者：
Budczies J;von Winterfeld M;Klauschen F;Bockmayr M;Lennerz JK;Denkert C;Wolf T;Warth A;Dietel M;Anagnostopoulos I;Weichert W;Wittschieber D;Stenzinger A
通讯作者：
Stenzinger A
影响因子：
78.5
作者：
Klein, Christoph A.
通讯作者：
Klein, Christoph A.
影响因子：
7.3
作者：
Cummings, Margaret C.;Simpson, Peter T.;Reid, Lynne E.;Jayanthan, Janani;Skerman, Joanna;Song, Sarah;Reed, Amy E. McCart;Kutasovic, Jamie R.;Morey, Adrienne L.;Marquart, Louise;O'Rourke, Peter;Lakhani, Sunil R.
通讯作者：
Lakhani, Sunil R.
影响因子：
4.6
作者：
AuBuchon, J. P.;de Wildt-Eggen, J.;Dumont, L. J.
通讯作者：
Dumont, L. J.