Comparison of Novel Oral Anticoagulants and Vitamin K Antagonists in Patients With Cerebral Venous Sinus Thrombosis on Efficacy and Safety: A Systematic Review.
Comparison of Novel Oral Anticoagulants and Vitamin K Antagonists in Patients With Cerebral Venous Sinus Thrombosis on Efficacy and Safety: A Systematic Review.
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新型口服抗凝剂和维生素 K 拮抗剂对脑静脉窦血栓形成患者的疗效和安全性比较：系统评价
DOI：
10.3389/fneur.2020.597623
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发表时间：
2020
影响因子：
3.4
通讯作者：
Yu J
中科院分区：
文献类型：
--
作者：
Li H;Yao M;Liao S;Chen J;Yu J
Vitamin K antagonists (VKAs) are guideline-suggested subacute anticoagulants for cerebral venous sinus thrombosis (CVST), although there is potential hemorrhage risk in clinical use. In the last decade, novel oral anticoagulants (NOACs) have been applied as an alternative to VKAs in some kinds of thromboembolic diseases. Whether NOACs could replace VKAs in CVST treatment remains unclear. We conducted a comparison between the two types of medicines on efficacy and safety for the treatment of CVST based on the present clinical evidence from a literature search. Six studies [four retrospective studies, one prospective study, and 1 randomized clinical trial (RCT)] including 398 patients were included. Data suggested no significant difference between NOACs and VKAs in terms of recurrence of venous thrombotic events (VTEs) or death [risk ratio (RR) = 0.34, 95% confidence interval (CI) 0.06–1.98], partial recanalization (RR = 0.97, 95% CI 0.93–1.14), and overall hemorrhage events (RR = 0.86, 95% CI 0.47–1.58). In conclusion, the application of NOACs for CVST is similar to that of VKAs in terms of efficacy and safety.
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影响因子：
168.9
作者：
Ruff, Christian T.;Giugliano, Robert P.;Antman, Elliott M.
通讯作者：
Antman, Elliott M.
影响因子：
8.3
作者：
Geisbuesch, Christina;Richter, Daniel;Nagel, Simon
通讯作者：
Nagel, Simon
影响因子：
4
作者：
Lee, Grace K. H.;Chen, Vanessa H.;Tan, Benjamin Y. Q.
通讯作者：
Tan, Benjamin Y. Q.
影响因子：
2.9
作者：
Lurkin, Antoine;Derex, Laurent;Dargaud, Yesim
通讯作者：
Dargaud, Yesim
影响因子：
8.3
作者：
Coutinho, Jonathan M.;Zuurbier, Susanna M.;Stam, Jan
通讯作者：
Stam, Jan