Co-occurrence and Severity of Neurodevelopmental Burden (Cognitive Impairment, Cerebral Palsy, Autism Spectrum Disorder, and Epilepsy) at Age Ten Years in Children Born Extremely Preterm.
Co-occurrence and Severity of Neurodevelopmental Burden (Cognitive Impairment, Cerebral Palsy, Autism Spectrum Disorder, and Epilepsy) at Age Ten Years in Children Born Extremely Preterm.
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DOI：
10.1016/j.pediatrneurol.2017.11.002
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发表时间：
2018-03
影响因子：
3.8
通讯作者：
ELGAN Study Investigators
中科院分区：
文献类型：
--
作者：
Hirschberger RG;Kuban KCK;O'Shea TM;Joseph RM;Heeren T;Douglass LM;Stafstrom CE;Jara H;Frazier JA;Hirtz D;Rollins JV;Paneth N;ELGAN Study Investigators
确定极早产儿（胎龄<28周）10岁时孤立性和多发性神经发育障碍的患病率，并为神经功能限制的分类提供一个框架。一项多中心、前瞻性队列随访研究（极低出生年龄新生儿研究）招募了889名2002-2004年出生的10岁儿童（合格儿童的92%）。我们评估了认知障碍的患病率，通过智商（IQ）和执行功能测试、脑瘫（CP）、自闭症谱系障碍（ASD）和癫痫单独和联合进行测量。损伤严重程度的三个级别为：I类：无重大神经发育损伤。第二类：认知能力正常的CP，ASD和/或癫痫。第三类：有认知障碍的儿童。873名儿童中有214名（25%）患有认知障碍，849名儿童中有93名（11%）患有CP，857名儿童中有61名（7%）患有ASD，888名儿童中有66名（7%）患有癫痫。19%的儿童有1个诊断，10%有2个诊断，3%有3个诊断，没有4个诊断。胎龄越小，损伤的数量越多（p<0.001）。一半的认知障碍儿童和三分之一的CP、ASD或癫痫儿童有单一的障碍。601例（68% [95% CI，64.5%-70.7%]）儿童属于I类，74例（8% [95% CI，6.6%-10.3%]）属于II类，214例（24% [95% CI，21.7%-27.4%]）属于III类。四分之三的儿童在10岁时智力正常;近70%的儿童没有神经发育障碍。40%的残疾人有多个诊断。
To determine the prevalence of isolated and multiple neurodevelopmental impairments at age 10 years among children born extremely preterm (<28 weeks gestational age) and to offer a framework for categorizing neurological limitations. A multicenter, prospective cohort follow-up study (Extremely Low Gestational Age Newborn Study) recruited 889 10 year-old children (92% of eligible children) born from 2002–2004. We assessed prevalence of cognitive impairment, measured by intelligent quotient (IQ) and tests of executive function, cerebral palsy (CP), autistic spectrum disorder (ASD), and epilepsy singly and in combination. The three-levels of impairment severity were: Category I: no major neurodevelopmental impairment. Category II: normal cognitive ability with CP, ASD, and/or epilepsy. Category III: children with cognitive impairment. 214 of 873 children (25%) had cognitive impairment, 93 of 849 children (11%) had CP, 61 of 857 children (7%) had ASD, and 66 of 888 children (7%) had epilepsy. 19% of all children had 1 diagnosis, 10% had 2 diagnoses, 3% had 3 diagnoses, and none had 4 diagnoses. Decreasing gestational age was associated with increasing number of impairments (p<0.001). Half the children with cognitive impairment and a third of children with CP, ASD, or epilepsy had a single impairment. 601 (68% [95% CI, 64.5%–70.7%]) of children were in Category I, 74 (8% [95% CI, 6.6%–10.3%]) were in Category II, and 214 (24% [95% CI 21.7%–27.4%]) were in Category III. Three quarters of children had normal intellect at age 10 years; nearly 70% were free of neurodevelopmental impairment. 40% of those with impairments had multiple diagnoses.
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影响因子：
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作者：
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通讯作者：
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影响因子：
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