Impact of acute TTE-evidenced cardiac dysfunction on in-hospital and outpatient mortality: A multicenter NYC COVID-19 registry study.
Impact of acute TTE-evidenced cardiac dysfunction on in-hospital and outpatient mortality: A multicenter NYC COVID-19 registry study.
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DOI：
10.1371/journal.pone.0283708
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发表时间：
2023
期刊：
影响因子：
3.7
通讯作者：
中科院分区：
文献类型：
--
作者：
COVID-19 is associated with cardiac dysfunction. This study tested the relative prognostic role of left (LV), right and bi- (BiV) ventricular dysfunction on mortality in a large multicenter cohort of patients during and after acute COVID-19 hospitalization. All hospitalized COVID-19 patients who underwent clinically indicated transthoracic echocardiography within 30 days of admission at four NYC hospitals between March 2020 and January 2021 were studied. Images were re-analyzed by a central core lab blinded to clinical data. Nine hundred patients were studied (28% Hispanic, 16% African-American), and LV, RV and BiV dysfunction were observed in 50%, 38% and 17%, respectively. Within the overall cohort, 194 patients had TTEs prior to COVID-19 diagnosis, among whom LV, RV, BiV dysfunction prevalence increased following acute infection (p<0.001). Cardiac dysfunction was linked to biomarker-evidenced myocardial injury, with higher prevalence of troponin elevation in patients with LV (14%), RV (16%) and BiV (21%) dysfunction compared to those with normal BiV function (8%, all p<0.05). During in- and out-patient follow-up, 290 patients died (32%), among whom 230 died in the hospital and 60 post-discharge. Unadjusted mortality risk was greatest among patients with BiV (41%), followed by RV (39%) and LV dysfunction (37%), compared to patients without dysfunction (27%, all p<0.01). In multivariable analysis, any RV dysfunction, but not LV dysfunction, was independently associated with increased mortality risk (p<0.01). LV, RV and BiV function declines during acute COVID-19 infection with each contributing to increased in- and out-patient mortality risk. RV dysfunction independently increases mortality risk.
COVID-19 is associated with cardiac dysfunction. This study tested the relative prognostic role of left (LV), right and bi- (BiV) ventricular dysfunction on mortality in a large multicenter cohort of patients during and after acute COVID-19 hospitalization. All hospitalized COVID-19 patients who underwent clinically indicated transthoracic echocardiography within 30 days of admission at four NYC hospitals between March 2020 and January 2021 were studied. Images were re-analyzed by a central core lab blinded to clinical data. Nine hundred patients were studied (28% Hispanic, 16% African-American), and LV, RV and BiV dysfunction were observed in 50%, 38% and 17%, respectively. Within the overall cohort, 194 patients had TTEs prior to COVID-19 diagnosis, among whom LV, RV, BiV dysfunction prevalence increased following acute infection (p<0.001). Cardiac dysfunction was linked to biomarker-evidenced myocardial injury, with higher prevalence of troponin elevation in patients with LV (14%), RV (16%) and BiV (21%) dysfunction compared to those with normal BiV function (8%, all p<0.05). During in- and out-patient follow-up, 290 patients died (32%), among whom 230 died in the hospital and 60 post-discharge. Unadjusted mortality risk was greatest among patients with BiV (41%), followed by RV (39%) and LV dysfunction (37%), compared to patients without dysfunction (27%, all p<0.01). In multivariable analysis, any RV dysfunction, but not LV dysfunction, was independently associated with increased mortality risk (p<0.01). LV, RV and BiV function declines during acute COVID-19 infection with each contributing to increased in- and out-patient mortality risk. RV dysfunction independently increases mortality risk.
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DOI：
10.1016/j.echo.2016.05.002
发表时间：
2016-09-01
影响因子：
6.5
作者：
Kim, Jiwon;Srinivasan, Aparna;Weinsaft, Jonathan W.
通讯作者：
Weinsaft, Jonathan W.
影响因子：
6
作者：
Mccullough, S. Andrew;Goyal, Parag;Okin, Peter M.
通讯作者：
Okin, Peter M.
影响因子：
2.8
作者：
Devereux, Richard B.;de Simone, Giovanni;Arnett, Donna K.;Best, Lyle G.;Boerwinkle, Eric;Howard, Barbara V.;Kitzman, Lane;Lee, Elisa T.;Mosley, Thomas H., Jr.;Weder, Alan;Roman, Mary J.
通讯作者：
Roman, Mary J.
影响因子：
3.8
作者：
Lassen MCH;Skaarup KG;Lind JN;Alhakak AS;Sengeløv M;Nielsen AB;Espersen C;Ravnkilde K;Hauser R;Schöps LB;Holt E;Johansen ND;Modin D;Djernaes K;Graff C;Bundgaard H;Hassager C;Jabbari R;Carlsen J;Lebech AM;Kirk O;Bodtger U;Lindholm MG;Joseph G;Wiese L;Schiødt FV;Kristiansen OP;Walsted ES;Nielsen OW;Madsen BL;Tønder N;Benfield T;Jeschke KN;Ulrik CS;Knop FK;Lamberts M;Sivapalan P;Gislason G;Marott JL;Møgelvang R;Jensen G;Schnohr P;Søgaard P;Solomon SD;Iversen K;Jensen JUS;Schou M;Biering-Sørensen T
通讯作者：
Biering-Sørensen T
影响因子：
2.7
作者：
Bioh G;Botrous C;Howard E;Patel A;Hampson R;Senior R
通讯作者：
Senior R