Environmental Factors for Epstein-Barr Virus Reactivation in a High-Risk Area of Nasopharyngeal Carcinoma: A Population-Based Study.
Environmental Factors for Epstein-Barr Virus Reactivation in a High-Risk Area of Nasopharyngeal Carcinoma: A Population-Based Study.
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DOI：
10.1093/ofid/ofac128
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发表时间：
2022-05
影响因子：
4.2
通讯作者：
Ye, Weimin
中科院分区：
文献类型：
--
作者：
Chen, Yufeng;Chang, Ellen T.;Liu, Qing;Cai, Yonglin;Zhang, Zhe;Chen, Guomin;Huang, Qi-Hong;Xie, Shang-Hang;Cao, Su-Mei;Jia, Wei-Hua;Zheng, Yuming;Li, Yancheng;Lin, Longde;Ernberg, Ingemar;Huang, Guangwu;Zeng, Yi-Xin;Adami, Hans-Olov;Ye, Weimin
关键词：
EB病毒(Epstein-Barr Virus，EBV)从潜伏感染到裂解感染的再激活是鼻咽癌发生的关键步骤。然而，关于EBV在人群水平上重新激活的环境风险因素的流行病学证据仍然很少。我们从广东和广西的普通人群中随机抽取了1916名成年人中国，从2010年到2014年。有关环境因素的信息是通过结构化访谈收集的。采用酶联免疫吸附试验检测血清中抗EB病毒衣壳抗原和核抗原1的免疫球蛋白A抗体，以评价EB病毒的激活状态。我们使用Logistic回归来计算EBV重新激活与各种环境因素相关的优势比(OR)和95%的可信区间(CI)。EBV的重新激活与广泛的环境因素之间没有相关性，包括饮酒或喝茶、慢性耳鼻咽喉疾病史、药物或草药的使用、咸鱼或腌制食品的消费、口腔卫生、兄弟姐妹关系以及各种住宅和职业暴露。只有吸烟与EB病毒重新激活有关(当前吸烟者与从不吸烟者；OR = 1.37；95%CI = 1.02-1.83)，随着吸烟强度、持续时间和吸烟年限的增加，暴露-反应呈阳性趋势。与之前的研究一致，我们发现吸烟和EBV重新激活之间存在关联。其他被检查的暴露与EBV重新激活无关。这些无效的结果可能表明暴露和EBV重新激活之间的更复杂的相互作用，或者宿主和/或病毒遗传变异的主导作用。除吸烟外，暴露于各种稳定的环境因素与EB病毒的重新激活无关。我们的主要无效发现表明，稳定的环境因素不太可能是EBV重新激活的主要决定因素。
Epstein-Barr virus (EBV) reactivation from latent to lytic infection has been considered as a key step in nasopharyngeal carcinoma oncogenesis. However, epidemiological evidence regarding environmental risk factors for EBV reactivation on a population level remains largely lacking. We enrolled 1916 randomly selected adults from the general population of Guangdong and Guangxi, China, from 2010 to 2014. Information on environmental factors was collected via a structured interview. Serum immunoglobulin A antibodies against EBV viral capsid antigen and nuclear antigen 1 were measured by enzyme-linked immunosorbent assay to evaluate EBV reactivation status. We used logistic regression to calculate odds ratios (ORs) with 95% confidence intervals (CIs) for the associations of EBV reactivation with various environmental factors. No associations were observed between EBV reactivation and extensive environmental factors, including alcohol or tea drinking, a history of chronic ear/nose/throat diseases, use of medications or herbs, consumption of salted fish or preserved foods, oral hygiene, sibship structure, and various residential and occupational exposures. Only cigarette smoking was associated with EBV reactivation (current smokers vs never smokers; OR = 1.37; 95% CI = 1.02–1.83), with positive exposure-response trends with increasing intensity, duration, and pack-years of smoking. Consistent with previous studies, we found an association between cigarette smoking and EBV reactivation. Other examined exposures were not associated with EBV reactivation. These null results could suggest either more complex interactions between exposures and EBV reactivation or a predominant role of host and/or viral genetic variation. Exposure to an extensive variety of stable environmental factors, with the exception of cigarette smoking, is not associated with EBV reactivation. Our predominantly null findings suggest that stable environmental factors are unlikely to be major determinants of EBV reactivation.
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影响因子：
4.2
作者：
Mai ZM;Lin JH;Ngan RK;Kwong DL;Ng WT;Ng AW;Ip KM;Chan YH;Lee AW;Ho SY;Lung ML;Lam TH
通讯作者：
Lam TH
影响因子：
8.8
作者：
通讯作者：
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影响因子：
50.5
作者：
Ji, M. F.;Sheng, W.;Cao, S. M.
通讯作者：
Cao, S. M.
影响因子：
5
作者：
Liu, Zhiwei;Ji, Ming-Fang;Cao, Su-Mei
通讯作者：
Cao, Su-Mei
影响因子：
3.8
作者：
Chen Y;Xu Y;Zhao W;Xiao X;Zhou X;Lin L;Huang T;Liao J;Li Y;Zeng X;Huang G;Ye W;Zhang Z
通讯作者：
Zhang Z