Lack of association between cigarette smoking and Epstein Barr virus reactivation in the nasopharynx in people with elevated EBV IgA antibody titres.
Lack of association between cigarette smoking and Epstein Barr virus reactivation in the nasopharynx in people with elevated EBV IgA antibody titres.
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DOI：
10.1186/s12885-018-4110-6
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发表时间：
2018-02-14
期刊：
影响因子：
3.8
通讯作者：
Zhang Z
中科院分区：
文献类型：
--
作者：
Chen Y;Xu Y;Zhao W;Xiao X;Zhou X;Lin L;Huang T;Liao J;Li Y;Zeng X;Huang G;Ye W;Zhang Z
eb病毒（EBV）免疫球蛋白A （IgA）滴度升高的受试者发生鼻咽癌（NPC）的风险更高，提示EBV在局部粘膜的再激活可能对鼻咽癌的发生有重要作用。吸烟似乎是鼻咽癌的环境危险因素之一。然而，吸烟诱导的鼻咽癌发生是否通过鼻咽粘膜EBV的再激活而起作用尚不清楚。因此，本研究旨在探讨吸烟与鼻咽癌高危人群鼻咽部EBV再激活之间的关系。一项基于人群的鼻咽癌筛查项目建立了一项鼻咽癌高危队列研究，其中包括1045名血清中针对EBV病毒衣壳抗原（VCA/IgA）的IgA抗体升高的受试者。在高危人群中，收集了313名男性受试者详细的吸烟史信息。分析吸烟与鼻咽部EBV抗体水平、EBV DNA载量的关系。鼻咽部EBV DNA载量或血清VCA/IgA滴度与吸烟状况、开始吸烟年龄、每日吸烟强度、吸烟持续时间、香烟类型或吸烟包年之间均未观察到显著相关性。所有亚组的吸烟特征与鼻咽EBV DNA阳性或EBV VCA/IgA血清阳性无关。在鼻咽癌高危人群中，我们的研究表明吸烟与鼻咽EBV DNA载量和血清VCA/IgA抗体水平无关。吸烟相关的鼻咽癌可能通过其他机制发生，而不是通过重新激活鼻咽EBV复制。
Subjects with elevated Epstein-Barr virus (EBV) immunoglobulin A (IgA) titers have a higher risk of developing nasopharyngeal carcinoma (NPC), indicating that reactivation of EBV in the local mucosa might be important for NPC carcinogenesis. Cigarette smoking appears to be one of the environmental risk factors for NPC. However, it remains unclear whether smoking-induced nasopharyngeal carcinogenesis acts through reactivating EBV in the nasopharyngeal mucosa. Therefore, this study aims to investigate the association between cigarette smoking and nasopharyngeal EBV reactivation in a NPC high-risk population. A NPC high-risk cohort study, established from a population-based NPC screening program of 22,816 subjects, consisted of 1045 subjects with elevated serum IgA antibodies against EBV viral capsid antigen (VCA/IgA). Among high-risk subjects, information on detailed cigarette smoking history was collected among 313 male subjects. The associations between cigarette smoking and EBV antibody levels, EBV DNA load of the nasopharynx were analyzed. No significant association was observed between either nasopharyngeal EBV DNA load or serum VCA/IgA titers and smoking status, age at smoking initiation, daily smoking intensity, smoking duration, cigarette type, or pack-years of smoking. Cigarette smoking characteristics in all subgroups did not correlate with nasopharyngeal EBV DNA positivity or EBV VCA/IgA seropositivity. In a population at high risk of NPC, our study suggests that cigarette smoking is neither associated with nasopharyngeal EBV DNA load nor serum VCA/IgA antibody level. Smoking-associated NPC carcinogenesis may act through other mechanisms than reactivating nasopharyngeal EBV replication.
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影响因子：
2.3
作者：
Xie, Shao-Hua;Yu, Ignatius Tak-sun;Lau, June Sze Man
通讯作者：
Lau, June Sze Man
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影响因子：
4
作者：
Zeng Q;Shen LJ;Li S;Chen L;Guo X;Qian CN;Wu PH
通讯作者：
Wu PH
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影响因子：
8.8
作者：
Feng, B-J;Khyatti, M.;Ben-Ayoub, W.;Dahmoul, S.;Ayad, M.;Maachi, F.;Bedadra, W.;Abdoun, M.;Mesli, S.;Bakkali, H.;Jalbout, M.;Hamdi-Cherif, M.;Boualga, K.;Bouaouina, N.;Chouchane, L.;Benider, A.;Ben-Ayed, F.;Goldgar, D. E.;Corbex, M.
通讯作者：
Corbex, M.
影响因子：
5.8
作者：
Nielsen, T. R.;Pedersen, M.;Hjalgrim, H.
通讯作者：
Hjalgrim, H.
影响因子：
20.3
作者：
Levin, Lynn I.;Chang, Ellen T.;Mueller, Nancy E.
通讯作者：
Mueller, Nancy E.