Syndrome of inappropriate antidiuresis in the absence of arginine vasopressin.
Syndrome of inappropriate antidiuresis in the absence of arginine vasopressin.
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缺乏精氨酸加压素时不适当抗利尿综合征。
DOI：
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发表时间：
1986
影响因子：
5.8
通讯作者：
J. G. Verbalis
中科院分区：
文献类型：
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作者：
Philip A. Kern;Richard J. Robbins;D. Bichet;Tomas Berl;J. G. Verbalis
不适当抗利尿综合征 (SIAD) 通常与血浆精氨酸加压素 (AVP) 浓度不当升高有关。我们在此描述了一位患有泌乳素大瘤的患者，该患者因 SIAD 而出现症状性低钠血症。尽管患者过度口渴、严重血浆渗透压低和高渗尿，但未检测到可免疫测定的 AVP。在长期使用溴隐亭治疗期间，泌乳素瘤逐渐缩小，同时排泄水负荷的能力得到改善，口渴阈值正常化。此时，首次在高渗盐水输注期间可测量血浆免疫活性 AVP。经高压液相色谱分析，该免疫活性物质与AVP共洗脱。这些研究表明，该患者的 SIAD 是由于产生了一种与 AVP 不同的抗利尿物质，并与其泌乳素瘤相关。
The syndrome of inappropriate antidiuresis (SIAD) is usually associated with inappropriately elevated plasma arginine vasopressin (AVP) concentrations. We describe herein a patient with a macroprolactinoma who had symptomatic hyponatremia due to SIAD. Although the patient had excessive thirst, severe plasma hypoosmolality, and hyperosmolar urine, no immunoassayable AVP could be detected. During long term treatment with bromocriptine, there was gradual shrinkage of the prolactinoma coincident with improvement in the ability to excrete a water load and normalization of the thirst threshold. At this point, plasma immunoactive AVP was measurable during a hypertonic saline infusion for the first time. By high pressure liquid chromatographic analysis, this immunoactive substance coeluted with AVP. These studies suggest that the SIAD in this patient was due to the production of an antidiuretic substance distinct from AVP in association with his prolactinoma.
证明大鼠催乳素在大鼠中没有内在的抗利尿活性。
影响因子：
--
作者：
North,WG;Gellai,M;Sokol,HW;Adler,RA
通讯作者：
Adler,RA