Oocyte-specific linker histone
Oocyte-specific linker histone
复制标题
卵母细胞特异性连接组蛋白
作者：
Mamoru Tanaka;Takahide Teranishi;Masataka Furuya;Yudai Tanaka;Kazuhiro Minegishi;K. Miyakoshi;H. Ishimoto;Y. Yoshimura
真核 DNA 主要通过与称为组蛋白的小型碱性蛋白相互作用而组装成染色质。组蛋白有两种类型：核心组蛋白（Ha H2B、H3 和 H4）和连接组蛋白，例如 H1。每个核心组蛋白的两个分子形成一个八聚体，周围包裹着 146bp 的 DNA。核小体核心颗粒之间的 DNA 称为接头 DNA，由接头组蛋白结合。迄今为止，已在哺乳动物中鉴定出 H1 的八种亚型。其中六种统称为体细胞亚型，并指定为 Hla、Hlb、Hlc、Hld、Hle 和 Hl(0)。第七个亚型是 Hlt，仅在精母细胞中表达。我们发现了一种哺乳动物卵母细胞特异性连接组蛋白 Hlfoo，它与非洲爪蟾卵母细胞特异性连接组蛋白 B4 同源。连接组蛋白亚型表达的变化似乎是早期胚胎发育的一个重要特征。有几个例子表明特定连接组蛋白 H1 表达与发育过程中的特定转变相关。在海胆中，至少有六种不同的 H1 亚型。裂解阶段 H1 (cs-Hl)。构成受精后细胞快速分裂过程中连接组蛋白的主要形式。然后，数百个 α 亚型拷贝在早期胚胎发生中表达，并且这种表达
Eukaryotic DNA is assembled into chromatin primarily through interaction with small basic proteins described as histones. There are two types of histone: the core histone (Ha H2B, H3 and H4) and the linker histone such as H1. Two molecules of each of the core histones form an octamer, around which is wrapped 146bp of DNA. The DNA that is in between nucleosome core particles is called linker DNA that is bound by the linker histones. To date, eight subtypes of H1 have been identified in mammals. Six of these are collectively termed the somatic subtypes and are designated Hla, Hlb, Hlc, Hld, Hle, and Hl(0). The seventh subtype is Hlt, which is expressed only in spermatocytes. We discovered a mammalian oocytespecific linker histone, Hlfoo, which is homologous to Xenopus oocyte-specific linker histone B4”. A shift in the expression of linker histone subtype expression appears to be a great feature of early embryonic development. There are several examples of the association of a specific linker histone H1 expression with particular transitions during development. In sea urchin, there are at least six different H1 subtypes. A cleavage stage H1 (cs-Hl). constitutes the major form of linker histone during the rapid cellular divisions after fertilization. The several hundreds copies of the alpha subtype are then expressed in early embryogenesis and this expression
影响因子：
4.6
作者：
Mamoru Tanaka;Jon D. Hennebold;Jane L. Macfarlane;Eli Y. Adashi
通讯作者：
Mamoru Tanaka;Jon D. Hennebold;Jane L. Macfarlane;Eli Y. Adashi