Analysis of anemia and iron supplementation among glioblastoma patients reveals sex-biased association between anemia and survival.
Analysis of anemia and iron supplementation among glioblastoma patients reveals sex-biased association between anemia and survival.
复制标题
胶质母细胞瘤患者贫血和补铁的分析揭示了贫血和生存之间的性别偏见。
DOI：
10.1038/s41598-024-52492-8
复制
发表时间：
2024-01-29
影响因子：
4.6
通讯作者：
中科院分区：
文献类型：
--
作者：
胶质母细胞瘤患者贫血与预后之间的关系尚不清楚。我们分析了TriNetX研究网络中1346例组织学证实的成人胶质母细胞瘤患者的数据。在诊断后的6个月内，对中位血红蛋白和红细胞压积水平进行量化，并用于将患者分为贫血或非贫血。然后研究贫血患者贫血和补铁与中位总生存期（median- os）的关系。在1346例胶质母细胞瘤患者中，35.9%的男性和40.5%的女性患者根据基于血红蛋白的世卫组织指南被归类为贫血。在男性中，与匹配的非贫血男性相比，贫血与血红蛋白（HR 1.24; 95% CI 1.00-1.53）或基于血细胞比降的临界值（HR 1.28; 95% CI 1.03-1.59）的中位os降低相关。在女性中，贫血与血红蛋白（HR 1.00; 95% CI 0.78-1.27）或基于血细胞比降的临界值（HR 1.10; 95% CI 0.85-1.41）的中位os无关。贫血女性补充铁有增加中位os的趋势（HR 0.61; 95% CI 0.32-1.19），但没有达到统计学意义，而在贫血男性中没有发现显著关联（HR 0.85; 95% CI 0.41-1.75）。功能性转铁蛋白结合测定证实了切除患者样本的两性二态结合，表明铁生物学的潜在差异。胶质母细胞瘤患者的贫血表现出与生存率的性别特异性关联。
The association between anemia and outcomes in glioblastoma patients is unclear. We analyzed data from 1346 histologically confirmed adult glioblastoma patients in the TriNetX Research Network. Median hemoglobin and hematocrit levels were quantified for 6 months following diagnosis and used to classify patients as anemic or non-anemic. Associations of anemia and iron supplementation of anemic patients with median overall survival (median-OS) were then studied. Among 1346 glioblastoma patients, 35.9% of male and 40.5% of female patients were classified as anemic using hemoglobin-based WHO guidelines. Among males, anemia was associated with reduced median-OS compared to matched non-anemic males using hemoglobin (HR 1.24; 95% CI 1.00–1.53) or hematocrit-based cutoffs (HR 1.28; 95% CI 1.03–1.59). Among females, anemia was not associated with median-OS using hemoglobin (HR 1.00; 95% CI 0.78–1.27) or hematocrit-based cutoffs (HR: 1.10; 95% CI 0.85–1.41). Iron supplementation of anemic females trended toward increased median-OS (HR 0.61; 95% CI 0.32–1.19) although failing to reach statistical significance whereas no significant association was found in anemic males (HR 0.85; 95% CI 0.41–1.75). Functional transferrin-binding assays confirmed sexually dimorphic binding in resected patient samples indicating underlying differences in iron biology. Anemia among glioblastoma patients exhibits a sex-specific association with survival.
登录
查看更多内容
缺氧支持最终耗尽的 CD8 T 细胞的分化。
影响因子：
7.3
作者：
Bannoud N;Dalotto-Moreno T;Kindgard L;García PA;Blidner AG;Mariño KV;Rabinovich GA;Croci DO
通讯作者：
Croci DO
影响因子：
4.7
作者：
Guo Q;Li L;Hou S;Yuan Z;Li C;Zhang W;Zheng L;Li X
通讯作者：
Li X
影响因子：
7.3
作者：
Costa da Silva M;Breckwoldt MO;Vinchi F;Correia MP;Stojanovic A;Thielmann CM;Meister M;Muley T;Warth A;Platten M;Hentze MW;Cerwenka A;Muckenthaler MU
通讯作者：
Muckenthaler MU
DOI：
10.3390/ph11040094
发表时间：
2018-09-30
期刊：
Pharmaceuticals (Basel, Switzerland)
影响因子：
--
作者：
Busti F;Marchi G;Ugolini S;Castagna A;Girelli D
通讯作者：
Girelli D
影响因子：
5.6
作者：
Charriaut-Marlangue C;Besson VC;Baud O
通讯作者：
Baud O