In vitro antimicrobial sensitivity of enteric rods and pseudomonads from advanced adult periodontitis.

In vitro antimicrobial sensitivity of enteric rods and pseudomonads from advanced adult periodontitis.
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晚期成人牙周炎肠杆和假单胞菌的体外抗菌敏感性。

DOI:
10.1111/j.1399-302x.1990.tb00428.x
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发表时间:
1990
影响因子:
--
通讯作者:
Rams,TE
Rams,TE
中科院分区:
--
文献类型:
--
作者:
Slots,J;Feik,D;Rams,TE

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对844例成人牙周炎患者进行了肠杆菌和假单胞菌的流行率和体外抗菌药物敏感性检测。从13.5%的研究受试者中回收了这些微生物。环丙沙星表现出最高的抑制活性的14个口服抗菌药物测试。β-内酰胺类抗生素在很大程度上是无效的,四环素未能抑制大多数假单胞菌。体外敏感性数据表明,环丙沙星和甲硝唑联合治疗会导致龈下微生物群主要由链球菌组成。由于链球菌可以抑制几种假定的牙周病原体的生长,牙周袋中的“有益”链球菌群可能构成非常有吸引力的治疗结果。环丙沙星在治疗破坏性牙周炎中的可能作用还需临床对照研究来阐明。
The prevalence andin vitroantimicrobial sensitivity of isolates of enteric rods and pseudomonads was examined in 844 adult periodontitis patients. These organisms were recovered from 13.5% of the study subjects. Ciprofloxacin exhibited the highest inhibitory activity of the 14 oral antimicrobial agents tested. Beta‐lactam antibiotics were largely ineffective, and tetracycline failed to inhibit mostPseudomonasspecies.In vitrosensitivity data suggest that a subgingival microbiota comprising mainly streptococci would result from therapy that combined ciprofloxacin and metronidazole. Since streptococci may inhibit the growth of several putative periodontal pathogens, populations of “beneficial” streptococci in the periodontal pocket might constitute a very attractive therapeutic outcome. Controlled clinical studies are needed to clarify the possible role of ciprofloxacin in the treatment of destructive periodontitis.
抗葡萄球菌抗生素的蛋白质结合。
DOI: --
发表时间: 1986
影响因子: 5.2
作者:
R. Lacey;K. Barr
通讯作者: K. Barr
环丙沙星与其他药物联合对抗临床感兴趣的厌氧菌的体外活性。
DOI: --
发表时间: 1986
影响因子: 5.2
作者:
B. Watt;F. V. Brown
通讯作者: F. V. Brown
连续增加口服剂量后环丙沙星的药代动力学和耐受性
DOI: --
发表时间: 1986
影响因子: 4.9
作者:
T. Tartaglione;A. Raffalovich;W. Poynor;A. Espinel;T. Kerkering
通讯作者: T. Kerkering
环丙沙星和其他三种抗生素对抗脆弱拟杆菌的体外协同作用。
DOI: --
发表时间: 1987
期刊: Drugs under experimental and clinical research
影响因子: --
作者:
S. Esposito;A. Gupta;H. Thadepalli
通讯作者: H. Thadepalli
DOI: 10.1128/jcm.15.4.606-609.1982
发表时间: 1982-01-01
影响因子: 9.4
作者:
SLOTS, J
通讯作者: SLOTS, J