Skin Viral Infections: Host Antiviral Innate Immunity and Viral Immune Evasion.
Skin Viral Infections: Host Antiviral Innate Immunity and Viral Immune Evasion.
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DOI：
10.3389/fimmu.2020.593901
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发表时间：
2020
影响因子：
7.3
通讯作者：
MacLeod AS
中科院分区：
文献类型：
--
作者：
Lei V;Petty AJ;Atwater AR;Wolfe SA;MacLeod AS
皮肤是一个活跃的免疫器官，是抵御外界环境的第一道也是最大的防线。作为宿主与病原体之间的主要接触面，皮肤对病毒入侵者的早期免疫反应往往决定了感染的进程和严重程度。我们回顾了有关经典亲皮肤性病毒、致癌病毒和媒介传播的皮肤病毒的皮肤病毒入侵机制的现有文献。我们讨论了皮肤针对这些入侵病原体的先天性免疫病毒防御的进化机制，以及病毒为逃避免疫检测所采用的独特策略。我们还探讨了人口统计学和环境因素，如年龄、生物性别和皮肤微生物组，在改变宿主对病毒威胁的免疫反应中所起的作用。
The skin is an active immune organ that functions as the first and largest site of defense to the outside environment. Serving as the primary interface between host and pathogen, the skin’s early immune responses to viral invaders often determine the course and severity of infection. We review the current literature pertaining to the mechanisms of cutaneous viral invasion for classical skin-tropic, oncogenic, and vector-borne skin viruses. We discuss the skin’s evolved mechanisms for innate immune viral defense against these invading pathogens, as well as unique strategies utilized by the viruses to escape immune detection. We additionally explore the roles that demographic and environmental factors, such as age, biological sex, and the cutaneous microbiome, play in altering the host immune response to viral threats.
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影响因子：
3.8
作者：
Conway MJ;Londono-Renteria B;Troupin A;Watson AM;Klimstra WB;Fikrig E;Colpitts TM
通讯作者：
Colpitts TM
妊娠期寨卡病毒感染：病程和并发症的系统评价。
影响因子：
3.4
作者：
Chibueze EC;Tirado V;Lopes KD;Balogun OO;Takemoto Y;Swa T;Dagvadorj A;Nagata C;Morisaki N;Menendez C;Ota E;Mori R;Oladapo OT
通讯作者：
Oladapo OT
影响因子：
3.6
作者：
Glynn JR;Crampin AC;Ngwira BM;Ndhlovu R;Mwanyongo O;Fine PE
通讯作者：
Fine PE
影响因子：
6.7
作者：
Coates, Margaret;Blanchard, Sarah;Macleod, Amanda S.
通讯作者：
Macleod, Amanda S.
DOI：
10.1111/j.1742-4658.2009.07402.x
发表时间：
2009-12
期刊：
The FEBS journal
影响因子：
--
作者：
Akhtar J;Shukla D
通讯作者：
Shukla D