Long-latency afferent inhibition during selective finger movement.
Long-latency afferent inhibition during selective finger movement.
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选择性手指运动期间的长潜伏期传入抑制。
DOI：
10.1152/jn.00333.2005
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发表时间：
2005
影响因子：
2.5
通讯作者：
Hallett,Mark
中科院分区：
文献类型：
--
作者：
Voller,Bernhard;StClairGibson,Alan;Lomarev,Mikhail;Kanchana,Sulada;Dambrosia,James;Dang,Nguyet;Hallett,Mark
在休息时，刺激手的周围神经可以调节运动皮层的兴奋性，特别是，当间隔约200 ms时，会导致抑制（长潜伏期传入抑制；LAI）。环绕抑制（SI）是抑制不参与特定任务的邻近肌肉的过程。SI的神经元机制尚不清楚，LAI可能与此有关。采用经颅磁刺激（TMS）测量了有和无食指运动的手部两个功能不同的目标肌肉（指外展肌= ADM，第一背骨间肌= FDI）的运动诱发电位（MEPs）。电刺激在经颅磁刺激前180毫秒应用于第五指或食指。同位和异位手指刺激均导致LAI无运动。随着食指的运动，同种和异位刺激的运动输出进一步减少，而在运动的FDI中，同种和异位刺激均没有改变。此外，在非刺激运动试验中，尽管试图维持ADM处于静止状态，但LAI随着非故意共激活的数量而增加。然而，随着手指刺激的增加，尽管共激活，MEPs几乎没有增加。这些发现表明运动时LAI增加，可以增强SI。
Stimulation of a peripheral nerve of a hand at rest modulates excitability in the motor cortex and, in particular, leads to inhibition when applied at an interval of ∼200 ms (long-latency afferent inhibition; LAI). Surround inhibition (SI) is the process that inhibits neighboring muscles not involved in a particular task. The neuronal mechanisms of SI are not known, and it is possible that LAI might contribute to it. Using transcranial magnetic stimulation (TMS) with and without movement of the index finger, the motor-evoked potentials (MEPs) were measured of two functionally distinct target muscles of the hand (abductor digiti minimi muscle = ADM, 1st dorsal interosseus muscle = FDI). Electrical stimulation was applied 180 ms before TMS to either the fifth finger or the index finger. Both homotopic and heterotopic finger stimulation resulted in LAI without movement. With index finger movement, motor output further decreased with homo- and heterotopic stimulation in the ADM. In the moving FDI, however, there was no change with either homo- or heterotopic stimulation. Additionally, in the unstimulated movement trials, LAI increased with the amount of unintentional co-activation that occurred despite attempts to maintain the ADM at rest. However, with finger stimulation added, there were almost no increased MEPs despite co-activation. These findings suggest that LAI increases during movement and can enhance SI.
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