Biomarkers detected in cord blood predict vaccine responses in young infants.
Biomarkers detected in cord blood predict vaccine responses in young infants.
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DOI：
10.3389/fimmu.2023.1152538
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发表时间：
2023
影响因子：
7.3
通讯作者：
Sleasman, John W.
中科院分区：
文献类型：
--
作者：
Baloh, Carolyn H.;Venturi, Guglielmo M.;Fischer, Bernard M.;Sadder, Liane S.;Kim-Chang, Julie J.;Chan, Cliburn;De Paris, Kristina;Yin, Li;Aldrovandi, Grace M.;Goodenow, Maureen M.;Sleasman, John W.
关键词：
影响出生后第一年疫苗免疫启动的因素包括先天免疫和适应性免疫，但在理解这些因素如何维持健康婴儿的疫苗抗体水平方面存在差距。假设是与B细胞存活相关的生物特征最能预测一年时的持续疫苗IgG水平。对82名在美国接受标准推荐免疫接种的足月健康婴儿的血浆生物特征进行纵向研究，在出生时、6个月时完成初始疫苗系列后不久和12个月疫苗接种前监测与生发中心发育相关的15种血浆生物标志物浓度和B细胞亚群的变化。接种后百日咳杆菌、破伤风类毒素和结合型流感嗜血杆菌B（HiB）的抗体IgG水平是结果指标。使用最小绝对收缩和选择算子（lasso）回归模型，脐带血（CB）血浆IL-2、IL-17 A、IL-31和可溶性CD 14（sCD 14）与12个月时的百日咳IgG水平呈正相关，而CB血浆APRIL和IL-33浓度呈负相关。相反，sCD 14和APRIL的CB浓度与持续的破伤风IgG水平呈正相关。对18对母亲/新生儿的单独横断面分析表明，CB生物标志物不是由于经胎盘转移，而是由于胎儿/母亲界面的免疫激活。脐带血转换记忆B细胞百分比升高与12个月HiB IgG水平呈正相关。6个月和12个月时的BAFF浓度分别与百日咳和HiB IgG水平呈正相关。持续的B细胞免疫受到出生前开始的早期生命免疫动力学的高度影响。这一发现为了解衰老中心的发育如何影响健康婴儿的疫苗反应提供了重要的见解，并为研究损害婴儿免疫发育的条件提供了基础。
Factors influencing vaccine immune priming in the first year of life involve both innate and adaptive immunity but there are gaps in understanding how these factors sustain vaccine antibody levels in healthy infants. The hypothesis was that bioprofiles associated with B cell survival best predict sustained vaccine IgG levels at one year. Longitudinal study of plasma bioprofiles in 82 term, healthy infants, who received standard recommended immunizations in the United States, with changes in 15 plasma biomarker concentrations and B cell subsets associated with germinal center development monitored at birth, soon after completion of the initial vaccine series at 6 months, and prior to the 12-month vaccinations. Post vaccination antibody IgG levels to Bordetella pertussis, tetanus toxoid, and conjugated Haemophilus influenzae type B (HiB) were outcome measures. Using a least absolute shrinkage and selection operator (lasso) regression model, cord blood (CB) plasma IL-2, IL-17A, IL-31, and soluble CD14 (sCD14) were positively associated with pertussis IgG levels at 12 months, while CB plasma concentrations of APRIL and IL-33 were negatively associated. In contrast, CB concentrations of sCD14 and APRIL were positively associated with sustained tetanus IgG levels. A separate cross-sectional analysis of 18 mother/newborn pairs indicated that CB biomarkers were not due to transplacental transfer, but rather due to immune activation at the fetal/maternal interface. Elevated percentages of cord blood switched memory B cells were positively associated with 12-month HiB IgG levels. BAFF concentrations at 6 and 12 months were positively associated with pertussis and HiB IgG levels respectively. Sustained B cell immunity is highly influenced by early life immune dynamics beginning prior to birth. The findings provide important insights into how germinal center development shapes vaccine responses in healthy infants and provide a foundation for studies of conditions that impair infant immune development.
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DOI：
10.3390/v13071392
发表时间：
2021-07-17
期刊：
Viruses
影响因子：
--
作者：
Clemens EA;Alexander-Miller MA
通讯作者：
Alexander-Miller MA
影响因子：
13.3
作者：
Kalampokis, Ioannis;Venturi, Guglielmo M.;Poe, Jonathan C.;Dvergsten, Jeffrey A.;Sleasman, John W.;Tedder, Thomas F.
通讯作者：
Tedder, Thomas F.
影响因子：
5.5
作者：
Healy, C. Mary;Rench, Marcia A.;Patel, Divya
通讯作者：
Patel, Divya
影响因子：
20.3
作者：
Basso, K;Klein, U;Dalla-Favera, R
通讯作者：
Dalla-Favera, R
影响因子：
5.5
作者：
Barug, Daan;Berbers, Guy A. M.;Rots, Nynke Y.
通讯作者：
Rots, Nynke Y.