Bim Expression Modulates Branching Morphogenesis of the Epithelium and Endothelium.
Bim Expression Modulates Branching Morphogenesis of the Epithelium and Endothelium.
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DOI：
10.3390/biom12091295
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发表时间：
2022-09-14
期刊：
影响因子：
5.5
通讯作者：
Sheibani, Nader
中科院分区：
文献类型：
--
作者：
Sorenson, Christine M.;Song, Yong-Seok;Wang, Shoujian;Darjatmoko, Soesiawati R.;Saghiri, Mohammad Ali;Ranji, Mahsa;Sheibani, Nader
分支形态发生是器官发生过程中的一个关键发育过程，因此它的破坏经常会导致长期后果。肾脏和眼睛有许多共同的病因，这可能是由于发育分支形态发生和信号通路（包括细胞死亡）的相似使用。将细胞凋亡平衡向细胞凋亡倾斜会产生类似于乳头肾综合征中发生的输尿管芽和视网膜血管分支表型。在这里，为了比较细胞凋亡减少背景下的输尿管芽和视网膜血管分支，我们研究了 Bim（Bcl-2 的竞争力量）的影响。在后肾中，Bim 表达的缺乏增强了输尿管芽的分支，并增加了输尿管芽的长度、分支点和分支端点。不幸的是，输尿管芽分支的增强也伴随着分支缺陷的增加和其他不良后果。尽管我们确实看到肾单位数量和肾脏质量增加，但我们观察到肾小球塌陷。 Bim 表达缺失时的视网膜血管分支与输尿管芽相似，包括血管长度、分支长度、节段长度和分支间隔增加。因此，我们的研究强调了适当的 Bim 表达对输尿管芽和视网膜脉管系统的总长度和分支的影响。
Branching morphogenesis is a key developmental process during organogenesis, such that its disruption frequently leads to long-term consequences. The kidney and eye share many etiologies, perhaps, due to similar use of developmental branching morphogenesis and signaling pathways including cell death. Tipping the apoptotic balance towards apoptosis imparts a ureteric bud and retinal vascular branching phenotype similar to one that occurs in papillorenal syndrome. Here, to compare ureteric bud and retinal vascular branching in the context of decreased apoptosis, we investigated the impact of Bim, Bcl-2’s rival force. In the metanephros, lack of Bim expression enhanced ureteric bud branching with increases in ureteric bud length, branch points, and branch end points. Unfortunately, enhanced ureteric bud branching also came with increased branching defects and other undesirable consequences. Although we did see increased nephron number and renal mass, we observed glomeruli collapse. Retinal vascular branching in the absence of Bim expression had similarities with the ureteric bud including increased vascular length, branching length, segment length, and branching interval. Thus, our studies emphasize the impact appropriate Bim expression has on the overall length and branching in both the ureteric bud and retinal vasculature.
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