Macrophages in Atherosclerosis, First or Second Row Players?
Macrophages in Atherosclerosis, First or Second Row Players?
复制标题
田径运动员的宏观调控，第一排还是第二排？
DOI：
10.3390/biomedicines9091214
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发表时间：
2021-09-13
期刊：
影响因子：
4.7
通讯作者：
Meilhac O
中科院分区：
文献类型：
--
作者：
Checkouri E;Blanchard V;Meilhac O
巨噬细胞代表自世纪最早的研究以来在动脉粥样硬化背景下广泛描述的细胞类型。长期以来，它们的作用被认为在动脉粥样硬化的发作和恶化中占优势，特别是通过释放促炎细胞因子和脂质的不受控制的充血导致泡沫细胞的形成和随后的坏死核心而参与慢性炎症状态的建立。然而，最近来自小鼠模型的证据使用在斑块发育期间追踪血管平滑肌细胞（VSMCs）的优雅技术显示，驻留的VSMCs在对动脉损伤的响应中显示出令人印象深刻的塑性特性，允许它们在斑块内切换成不同的细胞类型，包括间充质样细胞、巨噬细胞样细胞和骨软骨样细胞。在这篇综述中，我们反对赞成或反对的论点，巨噬细胞与VSMCs在动脉粥样硬化的各个阶段的影响，包括动脉粥样硬化前，富脂泡沫细胞的形成，坏死核心和纤维帽的发展，以及钙化和斑块破裂。我们还分析了动物模型的相关性，用于研究人类动脉粥样硬化的病理生理机制，并讨论了潜在的治疗策略，靶向血管平滑肌细胞或巨噬细胞，以防止心血管事件的发展。总的来说，虽然已经从动物模型中取得了重大发现，但仍然需要努力更好地理解并因此预防人类动脉粥样硬化斑块的发展。
Macrophages represent a cell type that has been widely described in the context of atherosclerosis since the earliest studies in the 17th century. Their role has long been considered to be preponderant in the onset and aggravation of atherosclerosis, in particular by participating in the establishment of a chronic inflammatory state by the release of pro-inflammatory cytokines and by uncontrolled engorgement of lipids resulting in the formation of foam cells and later of the necrotic core. However, recent evidence from mouse models using an elegant technique of tracing vascular smooth muscle cells (VSMCs) during plaque development revealed that resident VSMCs display impressive plastic properties in response to an arterial injury, allowing them to switch into different cell types within the plaque, including mesenchymal-like cells, macrophage-like cells and osteochondrogenic-like cells. In this review, we oppose the arguments in favor or against the influence of macrophages versus VSMCs in all stages of atherosclerosis including pre-atherosclerosis, formation of lipid-rich foam cells, development of the necrotic core and the fibrous cap as well as calcification and rupture of the plaque. We also analyze the relevance of animal models for the investigation of the pathophysiological mechanisms of atherosclerosis in humans, and discuss potential therapeutic strategies targeting either VSMCs or macrophage to prevent the development of cardiovascular events. Overall, although major findings have been made from animal models, efforts are still needed to better understand and therefore prevent the development of atherosclerotic plaques in humans.
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影响因子：
39.3
作者：
Boren, Jan;Chapman, M. John;Ginsberg, Henry N.
通讯作者：
Ginsberg, Henry N.
影响因子：
5.3
作者：
Andreeva, ER;Pugach, IM;Orekhov, AN
通讯作者：
Orekhov, AN
影响因子：
56.9
作者：
BROWN, MS;GOLDSTEIN, JL
通讯作者：
GOLDSTEIN, JL
影响因子：
37.8
作者：
Barrett, Tessa J.;Distel, Emilie;Fisher, Edward A.
通讯作者：
Fisher, Edward A.
DOI：
10.1161/01.atv.0000131260.80316.37
发表时间：
2004-07-01
影响因子：
8.7
作者：
Argmann, CA;Sawyez, CG;Huff, MW
通讯作者：
Huff, MW