In vivo femtosecond laser subsurface scleral treatment in rabbit eyes.
In vivo femtosecond laser subsurface scleral treatment in rabbit eyes.
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DOI：
10.1002/lsm.20954
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发表时间：
2010-09
影响因子：
2.4
通讯作者：
Juhasz, Tibor
中科院分区：
文献类型：
--
作者：
Chai, Dongyul;Chaudhary, Gautam;Mikula, Eric;Sun, Hui;Kurtz, Ron;Juhasz, Tibor
青光眼的进展可以通过降低眼内压（IOP）来减少或延迟。飞秒激光手术的特性，例如显著减少的附带组织损伤，加上能够在巩膜中实现孤立的表面下手术效果，使该技术成为青光眼管理中有前途的候选技术。在这项初步研究中，我们证明了在兔眼巩膜中使用飞秒激光在体内创建部分厚度的皮下引流通道，以增加房水（AH）流出。沿着矩形光栅图案扫描调谐至1.7 μm波长的飞秒激光束，以在本初步研究中包括的四只家兔的每只眼睛的巩膜中创建部分厚度的皮下引流通道。在激光治疗前和治疗后20分钟测量IOP，以评估手术的急性效应。OCT图像证实了在活体兔眼中部分厚度的表面下巩膜通道的产生。治疗眼和对照眼的术前和术后IOP测量结果的比较显示，由于部分厚度巩膜通道的存在导致AH流出速率增加，导致眼内压降低。用波长为1.7 μm的飞秒激光在活体兔眼巩膜中建立了部分厚度的皮下引流通道。通过部分厚度通道实现的IOP降低表明在治疗IOP升高中的潜在效用。
The progression of glaucoma can be reduced or delayed by reducing intraocular pressure (IOP). The properties of femtosecond laser surgery, such as markedly reduced collateral tissue damage, coupled with the ability to achieve isolated subsurface surgical effects in the sclera, make this technology a promising candidate in glaucoma management. In this pilot study we demonstrate the in vivo creation of partial thickness subsurface drainage channels with the femtosecond laser in the sclera of rabbit eyes in order to increase aqueous humor (AH) outflow. A femtosecond laser beam tuned to a 1.7 μm wavelength was scanned along a rectangular raster pattern to create the partial thickness subsurface drainage channels in the sclera of one eye of each of the four rabbits included in this pilot study. IOP was measured before and 20 minutes after the laser treatment to evaluate the acute effect of the procedure. OCT images verified the creation of the partial thickness subsurface scleral channels in the eyes of the in vivo rabbits. Comparison of pre- and postoperative IOP measurements in treated and control eyes revealed a reduction in the intraocular pressure due to the increased rate of AH outflow resulted in by the presence of the partial thickness scleral channels. The creation of partial thickness subsurface drainage channels was demonstrated in the sclera of in vivo rabbit eyes with a 1.7 μm wavelength femtosecond laser. Reduction in IOP achieved by the partial thickness channels suggests potential utility in the treatment of elevated IOP.
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影响因子：
13.7
作者：
Tsai, JC;Johnson, CC;Dietrich, MS
通讯作者：
Dietrich, MS
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通讯作者：
Falck-Ytter, YT
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作者：
Heijl, A;Leske, MC;Hussein, M
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Hussein, M