Nanoscale Molecular Containers
Nanoscale Molecular Containers
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纳米级分子容器
DOI：
10.1002/chin.200224252
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
D. Rudkevich
中科院分区：
文献类型：
--
作者：
D. Rudkevich
在过去的几年里，在纳米级分子容器的设计和合成方面取得了突破性进展--空洞、(半)碳和胶囊。这些纳米空间被设计用于小分子和离子的选择性结合、分离和传感、分子传输和传递、活性中间体的稳定以及通过包裹进行催化。它们还模仿酶的疏水性口袋。自从20世纪80年代初第一个能够捕获单一溶剂或气体分子的中空杯芳烃(Collet，Cram和Gutsche)以来，这个领域已经发展到对内部尺寸为15-20A，内部体积为1500 A3的巨型空腔的研究。这反映了目前分子识别的趋势，一方面是迅速走向纳米技术和微细制造，另一方面是分子生物学。最近制备的纳米胶囊已准备好用于药物的包裹和它们在细胞膜中的主动传输/递送。空洞..。
Over the last few years, there has been a breakthrough in the design and synthesis of nanoscale molecular containers—cavitands, (hemi)carcerands, and capsules. These nanocavities are designed for selective binding, separation and sensing of smaller molecules and ions, molecular transport and delivery, stabilization of reactive intermediates, and catalysis through encapsulation. They also mimic the hydrophobic pockets of enzymes. The field has grown since the first hollow calixarenes of Collet, Cram, and Gutsche, which were able to trap a single solvent or gas molecule, in the early 1980s, to investigations of giant cavities of 15–20 A inner dimensions and 1500 A3 internal volume. This reflects current trends in molecular recognition which are rapidly moving towards nanotechnology and microfabrication on the one hand and molecular biology on the other. Recently prepared nanocavities are ready to be employed for encapsulation of drugs and their active transport/delivery through cell membranes. Cavity-contai...
DOI：
10.1073/pnas.92.26.12403
发表时间：
1995-12-19
影响因子：
11.1
作者：
Shimizu, KD;Rebek, J
通讯作者：
Rebek, J