Mitochondria: a kinase anchoring protein 1, a signaling platform for mitochondrial form and function.
Mitochondria: a kinase anchoring protein 1, a signaling platform for mitochondrial form and function.
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DOI：
10.1016/j.biocel.2013.12.012
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发表时间：
2014-03
影响因子：
4
通讯作者：
Strack, Stefan
中科院分区：
文献类型：
--
作者：
Merrill, Ronald A.;Strack, Stefan
关键词：
线粒体以其作为细胞发电厂的作用而闻名，但它们也充当信号中枢，调节细胞增殖、分化和生存。激酶锚定蛋白 1 (AKAP1) 是一种支架蛋白，可将蛋白激酶 A (PKA) 和其他信号蛋白以及 RNA 招募到线粒体外膜。因此，AKAP1 整合了几个第二信使级联来调节线粒体功能以及相关的生理和病理生理结果。在这里，我们回顾了目前已知的 AKAP1 大分子相互作用在健康和疾病状态（包括肥胖）中的情况。我们还讨论了动力相关蛋白 1 (Drp1)，一种催化线粒体裂变的酶，是神经元中 PKA/AKAP1 信号复合物的关键底物之一。最近的证据表明 AKAP1 在神经元发育和存活中具有关键作用，这是由 Drp1 的抑制性磷酸化和线粒体完整性的维持介导的。
Mitochondria are best known for their role as cellular power plants, but they also serve as signaling hubs, regulating cellular proliferation, differentiation, and survival. A kinase anchoring protein 1 (AKAP1) is a scaffold protein that recruits protein kinase A (PKA) and other signaling proteins, as well as RNA, to the outer mitochondrial membrane. AKAP1 thereby integrates several second messenger cascades to modulate mitochondrial function and associated physiological and pathophysiological outcomes. Here, we review what is currently known about AKAP1’s macromolecular interactions in health and disease states, including obesity. We also discuss dynamin-related protein 1 (Drp1), the enzyme that catalyzes mitochondrial fission, as one of the key substrates of the PKA/AKAP1 signaling complex in neurons. Recent evidence suggests that AKAP1 has critical roles in neuronal development and survival, which are mediated by inhibitory phosphorylation of Drp1 and maintenance of mitochondrial integrity.
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影响因子：
9.8
作者：
Merrill RA;Dagda RK;Dickey AS;Cribbs JT;Green SH;Usachev YM;Strack S
通讯作者：
Strack S
影响因子：
--
作者：
Grozdanov, Petar N.;Stocco, Douglas M.
通讯作者：
Stocco, Douglas M.
DOI：
10.1016/j.bbrc.2006.05.138
发表时间：
2006-07-21
影响因子：
3.1
作者：
Bridges, Dave;MacDonald, Justin A.;Moorhead, Greg B. G.
通讯作者：
Moorhead, Greg B. G.
影响因子：
4.8
作者：
Furusawa, M;Taira, T;Ariga, H
通讯作者：
Ariga, H
影响因子：
5
作者：
Abrenica, Bernard;AlShaaban, Mohamed;Czubryt, Michael P.
通讯作者：
Czubryt, Michael P.