Kiss your tail goodbye: the role of PARN, Nocturnin, and Angel deadenylases in mRNA biology.
Kiss your tail goodbye: the role of PARN, Nocturnin, and Angel deadenylases in mRNA biology.
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DOI：
10.1016/j.bbagrm.2012.12.004
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发表时间：
2013-06
影响因子：
4.7
通讯作者：
Wilusz, Jeffrey
中科院分区：
文献类型：
--
作者：
Godwin, Alan R.;Kojima, Shihoko;Green, Carla B.;Wilusz, Jeffrey
PARN, Nocturnin and Angel are three of the multiple deadenylases that have been described in eukaryotic cells. While each of these enzymes appear to target poly(A) tails for shortening and influence RNA gene expression levels and quality control, the enzymes differ in terms of enzymatic mechanisms, regulation and biological impact. The goal of this review is to provide an in depth biochemical and biological perspective of the PARN, Nocturnin and Angel deadenylases. Understanding the shared and unique roles of these enzymes in cell biology will provide important insights into numerous aspects of the post-transcriptional control of gene expression.
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