Elevated ZC3H15 increases HCC growth and predicts poor survival after surgical resection.
Elevated ZC3H15 increases HCC growth and predicts poor survival after surgical resection.
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ZC3H15 升高会增加 HCC 生长并预测手术切除后生存率较差
DOI：
10.18632/oncotarget.9361
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发表时间：
2016-06-14
期刊：
影响因子：
--
通讯作者：
Zhou WP
中科院分区：
文献类型：
--
作者：
Jiang BG;Wan ZH;Huang J;Li LM;Liu H;Fu SY;Yang Y;Zhang J;Yuan SX;Wang RY;Yang Y;Gu FM;Dong LW;Pan ZY;Zhou WP
锌指CCCH型15(ZC3H15)又称DRG家族调节蛋白1(DFRP1)，是一种高度保守的真核蛋白质，与活性翻译机制密切相关。本研究的目的是探讨ZC3H15在肝细胞癌中的临床意义和内在功能。我们构建了一个包含261个肿瘤和匹配的肝癌患者正常组织的队列。用免疫组织化学、免疫印迹和定量聚合酶链式反应检测ZC3H15蛋白和mRNA的表达水平。ZC3H15在大多数肝细胞癌中呈高表达，且ZC3H15高水平与高血清甲胎蛋白(AFP)水平(>；20 ng/m L)和血管侵犯显著相关。Kaplan-Meier和Cox回归分析显示，ZC3H15升高是肝癌特异性无病生存率(风险比，1.789；95%可信区间[95%CI]，1.298~2.466[P=0.0004])和总生存率(HR，1.613；95%CI，1.120~2.322，P=0.0101)的独立预测因素。ZC3H15与TRAF2的相互作用增加了NFκB信号的激活。提示ZC3H15是肝细胞癌患者的独立预后标志物，其临床病理与肿瘤侵袭和血清AFP水平有关。
Zinc finger CCCH-type containing 15 (ZC3H15), also known as DRG family regulatory protein 1 (DFRP1), is a highly conserved eukaryotic protein that associates with active translation machinery. The aim of our study was to explore the clinical relevance and intrinsic functions of ZC3H15 in hepatocellular carcinoma (HCC). We constructed a cohort with 261 tumor and matched normal tissues from HCC patients. ZC3H15 protein and mRNA levels were determined using immunohistochemistry, western blot analysis, and quantitative polymerase chain reaction. ZC3H15 was highly expressed in the majority of HCC cases, and high ZC3H15 levels were significantly associated with high serum a-fetoprotein (AFP) levels (>20 ng/mL) and vascular invasion. Kaplan-Meier and Cox regression data indicated that elevated ZC3H15 was an independent predictor for HCC-specific disease-free survival (hazards ratio [HR], 1.789; 95% confidence interval [95% CI], 1.298-2.466 [P=0.0004]) and overall survival (HR, 1.613; 95% CI, 1.120-2.322 [P=0.0101]). Interaction of ZC3H15 with TRAF2 increased activation of NFκB signaling. These results suggest ZC3H15 is an independent prognostic marker in HCC patients that is clinicopathologically associated with tumor invasion and serum AFP levels.
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