Role of connexin/pannexin containing channels in infectious diseases.
Role of connexin/pannexin containing channels in infectious diseases.
复制标题
连接性疾病中含有通道的连接蛋白/泛毒素的作用。
DOI：
10.1016/j.febslet.2014.01.030
复制
发表时间：
2014-04-17
期刊：
影响因子：
3.5
通讯作者：
Eugenin EA
中科院分区：
文献类型：
--
作者：
Eugenin EA
近年来，间隙连接和半通道，与细胞外ATP和嘌呤能受体一起，在一些生理过程和病理条件中起着关键作用。然而，直到最近才对它们在传染病中的重要性进行了探索，这可能是因为早期的报告表明，含有连接蛋白的通道在炎症条件下完全失活，因此没有进行进一步的研究。然而，最近的证据表明，一些感染因子利用这些通信系统来增强炎症和细胞凋亡，以及参与几种病原体的感染周期。在当前的综述中，我们将讨论这些通道/受体在几种传染病的发病机制中的作用，以及产生新的治疗方法来减少或预防这些疾病的可能性。
In recent years it has become evident that gap junctions and hemichannels, in concert with extracellular ATP and purinergic receptors, play key roles in several physiological processes and pathological conditions. However, only recently has their importance in infectious diseases been explored, likely because early reports indicated that connexin containing channels were completely inactivated under inflammatory conditions, and therefore no further research was performed. However, recent evidence indicates that several infectious agents take advantage of these communication systems to enhance inflammation and apoptosis, as well as to participate in the infectious cycle of several pathogens. In the current review, we will discuss the role of these channels/receptors in the pathogenesis of several infectious diseases and the possibilities of generating novel therapeutic approaches to reduce or prevent these diseases.
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影响因子：
3.4
作者：
Bachmann, M;Horn, K;Mühl, H
通讯作者：
Mühl, H
DOI：
10.1016/s0960-5428(06)80269-x
发表时间：
1994-01-01
期刊：
ADVANCES IN NEUROIMMUNOLOGY
影响因子：
--
作者：
CONANT, K;TORNATORE, C;MAJOR, EO
通讯作者：
MAJOR, EO
影响因子：
3.8
作者：
Bagasra, O;Lavi, E;Pomerantz, RJ
通讯作者：
Pomerantz, RJ
影响因子：
5.3
作者：
CROW, DS;BEYER, EC;LAU, AF
通讯作者：
LAU, AF
影响因子：
11.2
作者：
Churchill, Melissa J.;Wesselingh, Steven L.;Gorry, Paul R.
通讯作者：
Gorry, Paul R.