A prospective, seroepidemiological study of the role of human papillomavirus in esophageal cancer in Norway.
A prospective, seroepidemiological study of the role of human papillomavirus in esophageal cancer in Norway.
复制标题
一项关于人乳头瘤病毒在挪威食道癌中的作用的前瞻性血清流行病学研究。
作者：
T. Bjørge;T. Hakulinen;A. Engeland;E. Jellum;P. Koskela;M. Lehtinen;T. Luostarinen;J. Paavonen;M. Sapp;J. Schiller;S. Thoresen;Zhaohui Wang;L. Youngman;J. Dillner
在血清流行病学研究中，人乳头瘤病毒（HPV），特别是HPV 16型感染与食管癌相关。为了评估这种关联的一致性，我们在前瞻性随访的30万名挪威男性和女性队列中进行了一项HPV血清阳性和食管癌风险的巢式病例对照研究，这些男性和女性向血清库捐献了血液样本。将血清库的数据文件与挪威全国癌症登记处联系起来，以确定在捐赠血清样本后诊断的食管癌。分析了57例病例和171例匹配对照的特异性微生物抗体，并计算了发生食管癌的比值比。HPV 16血清阳性受试者发生食管癌的风险增加（比值比= 6.6; 95%置信区间，1.1-71），但沙眼衣原体血清阳性受试者中没有增加。调整血清可替宁的存在，吸烟习惯的标志物，并没有影响估计实质上。HPV 16与食管癌之间的血清流行病学关联在不同国家似乎是一致的。
Infection with the human papillomavirus (HPV), notably HPV type 16, has been associated with esophageal cancer in seroepidemiological studies. To evaluate the consistency of the association, we performed a nested case-control study of HPV seropositivity and risk of esophageal cancer within a prospectively followed cohort of 300,000 Norwegian men and women who had donated blood samples to a serum bank. The data file of the serum bank was linked with the nationwide Cancer Registry of Norway to identify esophageal cancers diagnosed after donation of the serum sample. Fifty-seven cases and 171 matched controls were analyzed for antibodies to specific microorganisms, and odds ratios for developing esophageal cancer were calculated. There was an increased risk of developing esophageal cancer among HPV 16-seropositive subjects (odds ratio = 6.6; 95% confidence interval, 1.1-71) but not among Chlamydia trachomatis-seropositive subjects. Adjustment for the presence of serum cotinine, a marker of smoking habits, did not affect the estimates substantially. The seroepidemiological association between HPV 16 and esophageal cancer seems to be consistent in different countries.
DOI：
10.1093/jnci/86.7.494
发表时间：
1994-04-06
期刊：
Journal of the National Cancer Institute
影响因子：
--
作者：
Kirnbauer R;Hubbert NL;Wheeler CM;Becker TM;Lowy DR;Schiller JT
通讯作者：
Schiller JT