Review: a role for the FGF receptor in the axonal growth response stimulated by cell adhesion molecules?
Review: a role for the FGF receptor in the axonal growth response stimulated by cell adhesion molecules?
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评论：FGF 受体在细胞粘附分子刺激的轴突生长反应中的作用？
DOI：
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
P. Doherty
中科院分区：
文献类型：
--
作者：
H. Hall;F. Walsh;P. Doherty
细胞粘附分子（CAMs）已被证明能刺激轴突生长。这种反应的分子基础已被广泛研究，一系列促进或抑制CAM刺激轴突生长的药物现已被确定。这些研究表明，在嗜同性和/或嗜异性相互作用后，CAM特异性信号转导通路被激活，这直接负责促进轴突生长。在这篇综述中，我们将提出三种cam （NCAM， N-cadherin和L1）刺激的轴突生长反应可以在操作上分为几个阶段。在第一阶段，轴突生长锥上表达的cam与细胞底物之间发生亲同性和/或异性结合。随后，神经元CAMs与成纤维细胞生长因子受体（FGFR）相互作用，通过自磷酸化导致受体活化。这导致额外的效应分子通过其SH2结构域与激活受体的相互作用而募集和激活。在这种情况下，神经突生长的关键事件似乎是磷脂酶C γ (PLC γ)的激活，它启动了第二个信使级联，最终导致与生长锥运动有关的细胞骨架元件的修饰，最有可能是磷酸化。
Cell adhesion molecules (CAMs) have been shown to stimulate axonal growth. The molecular basis of this response has been extensively studied and a range of agents that promote or inhibit CAM stimulated axonal growth have now been identified. These studies have led to the suggestion that following homophilic and/or heterophilic interactions CAM specific signal transduction pathways are activated which are directly responsible for promotion of axonal growth. In this review we will suggest that the axonal growth response stimulated by three CAMs (NCAM, N-cadherin and L1) can be operationally divided into a number of phases. During the first phase homophilic and/or heterophilic binding between the CAMs expressed on the axonal growth cone and cellular substrate take place. This is followed by an interaction of the neuronal CAMs with the fibroblast growth factor receptor (FGFR), leading to receptor activation by autophosphorylation. This results in the recruitment and activation of additional effector molecules via interactions of their SH2 domains with the activated receptor. In this context the key event in terms of neurite outgrowth appears to be the activation of phospholipase C gamma (PLC gamma) which sets into motion a second messenger cascade that ultimately leads to a modification, most likely by phosphorylation, of cytoskeletal elements that are involved in growth cone motility.
劳斯肉瘤病毒转化的鸡胚成纤维细胞中糖蛋白酪氨酸磷酸化。
影响因子：
5.3
作者：
Kozma,LM;Reynolds,AB;Weber,MJ
通讯作者：
Weber,MJ
DOI：
10.3109/15419069309095677
发表时间：
1993-01-01
期刊：
CELL ADHESION AND COMMUNICATION
影响因子：
--
作者：
EDELMAN, GM
通讯作者：
EDELMAN, GM
影响因子：
56.9
作者：
BAILEY, CH;CHEN, M;KANDEL, ER
通讯作者：
KANDEL, ER