Prostate cancer genomics: can we distinguish between indolent and fatal disease using genetic markers?
Prostate cancer genomics: can we distinguish between indolent and fatal disease using genetic markers?
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DOI：
10.1186/gm166
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发表时间：
2010-07-29
期刊：
影响因子：
12.3
通讯作者：
Wiklund F
中科院分区：
文献类型：
--
作者：
Wiklund F
前列腺癌是男性中遗传性最强的癌症之一，最近的全基因组关联研究揭示了许多与疾病相关的遗传变异。使用病例对照设计，将未受影响的个体与所有类型的前列腺癌患者进行比较，确定的风险变体显示出很少或没有能力区分这种疾病的惰性和致命形式。这表明与前列腺癌的预后相比，不同的遗传成分参与了前列腺癌的启动。未来的研究对比了更多和更少侵袭性疾病的患者，并探索与疾病进展和预后的相关性，应该更有效地检测前列腺癌预后的遗传风险因素。
Prostate cancer is one of the most heritable cancers in men, and recent genome-wide association studies have revealed numerous genetic variants associated with disease. The risk variants identified using case-control designs that compared unaffected individuals with all types of patients with prostate cancer show little or no ability to discriminate between indolent and fatal forms of this disease. This suggests different genetic components are involved in the initiation as compared with the prognosis of prostate cancer. Future studies contrasting patients with more and less aggressive disease, and exploring association with disease progression and prognosis, should be more effective in detecting genetic risk factors for prostate cancer outcome.
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影响因子：
254.7
作者：
Jemal, Ahmedin;Siegel, Rebecca;Thun, Michael J.
通讯作者：
Thun, Michael J.
影响因子：
30.8
作者：
Kiemeney LA;Thorlacius S;Sulem P;Geller F;Aben KK;Stacey SN;Gudmundsson J;Jakobsdottir M;Bergthorsson JT;Sigurdsson A;Blondal T;Witjes JA;Vermeulen SH;Hulsbergen-van de Kaa CA;Swinkels DW;Ploeg M;Cornel EB;Vergunst H;Thorgeirsson TE;Gudbjartsson D;Gudjonsson SA;Thorleifsson G;Kristinsson KT;Mouy M;Snorradottir S;Placidi D;Campagna M;Arici C;Koppova K;Gurzau E;Rudnai P;Kellen E;Polidoro S;Guarrera S;Sacerdote C;Sanchez M;Saez B;Valdivia G;Ryk C;de Verdier P;Lindblom A;Golka K;Bishop DT;Knowles MA;Nikulasson S;Petursdottir V;Jonsson E;Geirsson G;Kristjansson B;Mayordomo JI;Steineck G;Porru S;Buntinx F;Zeegers MP;Fletcher T;Kumar R;Matullo G;Vineis P;Kiltie AE;Gulcher JR;Thorsteinsdottir U;Kong A;Rafnar T;Stefansson K
通讯作者：
Stefansson K
影响因子：
2.1
作者：
Crawford, E. David
通讯作者：
Crawford, E. David
影响因子：
11.2
作者：
Hsu FC;Sun J;Wiklund F;Isaacs SD;Wiley KE;Purcell LD;Gao Z;Stattin P;Zhu Y;Kim ST;Zhang Z;Liu W;Chang BL;Walsh PC;Duggan D;Carpten JD;Isaacs WB;Grönberg H;Xu J;Zheng SL
通讯作者：
Zheng SL
DOI：
10.1186/bcr1737
发表时间：
2007
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Hartman M;Lindström L;Dickman PW;Adami HO;Hall P;Czene K
通讯作者：
Czene K