A small, variable, and irregular killer cell Ig-like receptor locus accompanies the absence of MHC-C and MHC-G in gibbons.
A small, variable, and irregular killer cell Ig-like receptor locus accompanies the absence of MHC-C and MHC-G in gibbons.
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长臂猿中 MHC-C 和 MHC-G 的缺失伴随着一个小的、可变的和不规则的杀伤细胞 Ig 样受体位点。
DOI：
10.4049/jimmunol.0903016
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发表时间：
2010-02-01
期刊：
影响因子：
--
通讯作者：
Walter L
中科院分区：
文献类型：
--
作者：
Abi-Rached L;Kuhl H;Roos C;ten Hallers B;Zhu B;Carbone L;de Jong PJ;Mootnick AR;Knaust F;Reinhardt R;Parham P;Walter L
自然杀伤（NK）细胞的杀伤细胞Ig样受体（KIR）识别主要组织相容性复合体（MHC）I类配体，并在胎盘生殖和针对病原体的免疫防御中起作用。在猴子、类人猿和人类的进化过程中，一个祖先KIR 3DL基因扩展成为一个由四个KIR谱系组成的多样化且快速进化的基因家族。表征KIR基因座的是三个框架区，定义了两个可变基因含量的区间。通过对两种巨猿的四种KIR单倍型的分析，我们发现小型类人猿不符合这些规则。虽然在结构上多样且不规则，但giglycoprotein单倍型非常小，仅包含2至5个功能基因。与预测的祖先类人猿KIR单倍型的比较表明，现代的gigliomas KIR单倍型是由一系列缺失事件形成的，这些事件产生了新的杂交基因，同时消除了祖先基因。在这三个框架区中，只有KIR 3DL 3（谱系V），定义了KIR基因座的5'端，在所有的giglycerKIR单倍型上都存在并且是完整的。KIR 2DL 4（谱系I）定义的中央框架区一直是消除或失活的主要目标，与缺乏其推定的配体，MHC-G，在长臂猿。类似地，在类人猿中MHC-C驱动的谱系III KIR基因的扩增在长臂猿中没有发生，因为它们缺乏MHC-C。我们的研究结果表明，选择性力量塑造的大小和组织的gigliosomal KIR基因座的不同，从那些作用于其他类人猿KIR。
The killer cell Ig-like receptors (KIR) of natural killer (NK) cells recognize major histocompatibility complex (MHC) class I ligands and function in placental reproduction and immune defense against pathogens. During the evolution of monkeys, great apes and humans, an ancestral KIR3DL gene expanded to become a diverse and rapidly evolving gene family of four KIR lineages. Characterising the KIR locus are three framework regions, defining two intervals of variable gene-content. By analysis of four KIR haplotypes from two species of gibbon, we find that the smaller apes do not conform to these rules. Although diverse and irregular in structure, the gibbon haplotypes are unusually small, containing only two to five functional genes. Comparison with the predicted ancestral hominoid KIR haplotype indicates that modern gibbon KIR haplotypes were formed by a series of deletion events, which created new hybrid genes as well as eliminating ancestral genes. Of the three framework regions, only KIR3DL3 (lineage V), defining the 5’ end of the KIR locus, is present and intact on all gibbon KIR haplotypes. KIR2DL4 (lineage I) defining the central framework region has been a major target for elimination or inactivation, correlating with the absence of its putative ligand, MHC-G, in gibbons. Similarly, the MHC-C driven expansion of lineage III KIR genes in great apes has not occurred in gibbons because they lack MHC-C. Our results indicate that the selective forces shaping the size and organisation of the gibbon KIR locus differed from those acting upon the KIR of other hominoid species.
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影响因子：
4.5
作者：
Averdam A;Petersen B;Rosner C;Neff J;Roos C;Eberle M;Aujard F;Münch C;Schempp W;Carrington M;Shiina T;Inoko H;Knaust F;Coggill P;Sehra H;Beck S;Abi-Rached L;Reinhardt R;Walter L
通讯作者：
Walter L
影响因子：
9.8
作者：
Feng J;Call ME;Wucherpfennig KW
通讯作者：
Wucherpfennig KW
影响因子：
3.2
作者：
Guethlein, Lisbeth A.;Abi-Rached, Laurent;Parham, Peter
通讯作者：
Parham, Peter
DOI：
10.1084/jem.20042558
发表时间：
2005-04-18
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Abi-Rached L;Parham P
通讯作者：
Parham P
影响因子：
6.4
作者：
Apps, Richard;Murphy, Shawn P.;Moffett, Ashley
通讯作者：
Moffett, Ashley