Global analysis of miRNA gene clusters and gene families reveals dynamic and coordinated expression.
Global analysis of miRNA gene clusters and gene families reveals dynamic and coordinated expression.
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DOI：
10.1155/2014/782490
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发表时间：
2014
影响因子：
--
通讯作者：
Chen F
中科院分区：
文献类型：
--
作者：
Guo L;Yang S;Zhao Y;Zhang H;Wu Q;Chen F
为了进一步了解miRNA基因簇和基因家族中miRNA的潜在表达关系，使用深度测序数据集在4个配对肿瘤（乳腺癌）和相邻正常组织样本中进行全局分析。miRNA基因簇和家族的组成不是随机的，成簇的和同源的miRNA可能与重叠的miRNA种类有密切的关系。miRNA组中的成员总是有不同的表达水平，甚至有些表现出较大的表达差异。尽管存在动态表达和个体差异，但这些miRNAs总是表现出一致或相似的失调模式。这种一致的去调控表达可能有助于调控网络中不同miRNA之间的动态和协调的相互作用。此外，我们发现，那些成簇或同源的miRNA，也被确定为正义和反义的miRNA显示出更大的表达差异。miRNA基因簇和家族具有重要的生物学作用，其特异性的分布和表达进一步丰富和保证了其灵活、稳健的调控网络。
To further understand the potential expression relationships of miRNAs in miRNA gene clusters and gene families, a global analysis was performed in 4 paired tumor (breast cancer) and adjacent normal tissue samples using deep sequencing datasets. The compositions of miRNA gene clusters and families are not random, and clustered and homologous miRNAs may have close relationships with overlapped miRNA species. Members in the miRNA group always had various expression levels, and even some showed larger expression divergence. Despite the dynamic expression as well as individual difference, these miRNAs always indicated consistent or similar deregulation patterns. The consistent deregulation expression may contribute to dynamic and coordinated interaction between different miRNAs in regulatory network. Further, we found that those clustered or homologous miRNAs that were also identified as sense and antisense miRNAs showed larger expression divergence. miRNA gene clusters and families indicated important biological roles, and the specific distribution and expression further enrich and ensure the flexible and robust regulatory network.
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影响因子：
3.7
作者：
Guo L;Yang Q;Lu J;Li H;Ge Q;Gu W;Bai Y;Lu Z
通讯作者：
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影响因子：
5
作者：
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影响因子：
3.1
作者：
Guo, Li;Lu, Zuhong
通讯作者：
Lu, Zuhong
影响因子：
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作者：
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通讯作者：
Marra, Marco A.
影响因子：
64.5
作者：
Lewis, BP;Shih, IH;Burge, CB
通讯作者：
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