Primary Cilia and Calcium Signaling Interactions.
Primary Cilia and Calcium Signaling Interactions.
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DOI：
10.3390/ijms21197109
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发表时间：
2020-09-26
影响因子：
5.6
通讯作者：
AbouAlaiwi W
中科院分区：
文献类型：
--
作者：
Saternos H;Ley S;AbouAlaiwi W
钙离子（Ca 2+）是一种多样的第二信使，在大量的细胞过程中几乎无处不在。纤毛以运动或非运动形式存在于几乎每种细胞类型上;运动纤毛产生各种生物过程所需的流体流动，例如发育期间的左右身体模式，而非运动纤毛作为细胞的信号动力室，具有定位于其睫状膜的重要单一受体。目前对Ca 2+依赖性细胞作用和初级纤毛的研究大多是组织特异性过程。然而，基本的刺激感测途径，如机械感觉，化学感觉，和电感觉（电感觉），是复杂的过程纠缠在许多交叉的途径;一个概述提出的功能，涉及纤毛和Ca 2+的相互作用将在这里简要总结。接下来，我们将重点总结它们在基本细胞活动中相互作用的证据，包括细胞周期，细胞极性和迁移，神经元模式，葡萄糖介导的胰岛素分泌，胆汁调节和骨形成。研究纤毛和Ca 2+依赖过程在单细胞水平上的作用的文献似乎很少，尽管重叠的信号传导途径意味着纤毛和Ca 2+在这个水平上以广泛和不同的方式相互作用。在许多不同的细胞类型中，非常不同的细胞功能取决于特定环境的Ca 2+和纤毛相互作用，以触发正确的生理反应，这些相互作用的异常，无论是在组织还是单细胞水平，都可能导致称为纤毛病的疾病;由于其临床意义，纤毛功能和Ca 2+信号的病理改变也将简要触及整个审查。
The calcium ion (Ca2+) is a diverse secondary messenger with a near-ubiquitous role in a vast array of cellular processes. Cilia are present on nearly every cell type in either a motile or non-motile form; motile cilia generate fluid flow needed for a variety of biological processes, such as left–right body patterning during development, while non-motile cilia serve as the signaling powerhouses of the cell, with vital singling receptors localized to their ciliary membranes. Much of the research currently available on Ca2+-dependent cellular actions and primary cilia are tissue-specific processes. However, basic stimuli-sensing pathways, such as mechanosensation, chemosensation, and electrical sensation (electrosensation), are complex processes entangled in many intersecting pathways; an overview of proposed functions involving cilia and Ca2+ interplay will be briefly summarized here. Next, we will focus on summarizing the evidence for their interactions in basic cellular activities, including the cell cycle, cell polarity and migration, neuronal pattering, glucose-mediated insulin secretion, biliary regulation, and bone formation. Literature investigating the role of cilia and Ca2+-dependent processes at a single-cellular level appears to be scarce, though overlapping signaling pathways imply that cilia and Ca2+ interact with each other on this level in widespread and varied ways on a perpetual basis. Vastly different cellular functions across many different cell types depend on context-specific Ca2+ and cilia interactions to trigger the correct physiological responses, and abnormalities in these interactions, whether at the tissue or the single-cell level, can result in diseases known as ciliopathies; due to their clinical relevance, pathological alterations of cilia function and Ca2+ signaling will also be briefly touched upon throughout this review.
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DOI：
10.1161/hypertensionaha.111.172080
发表时间：
2011-08
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Abdul-Majeed S;Nauli SM
通讯作者：
Nauli SM
影响因子：
15.9
作者：
Chauvet, V;Tian, X;Caplan, MJ
通讯作者：
Caplan, MJ
影响因子：
4.6
作者：
Corrigan MA;Johnson GP;Stavenschi E;Riffault M;Labour MN;Hoey DA
通讯作者：
Hoey DA
影响因子：
3.4
作者：
Brownell, William E.;Qian, Feng;Anvari, Bahman
通讯作者：
Anvari, Bahman
影响因子：
10.9
作者：
Benninger, Richard K. P.;Piston, David W.
通讯作者：
Piston, David W.