Flexible optoelectric neural interfaces.

Flexible optoelectric neural interfaces.
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DOI:
10.1016/j.copbio.2021.11.001
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发表时间:
2021-12
影响因子:
7.7
通讯作者:
--
中科院分区:
工程技术1区
文献类型:
--
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了解脑功能和功能障碍的神经基础并设计有效的治疗方法需要高分辨率的靶向刺激和记录神经活动。光学方法最近已经被开发用于神经刺激以及功能和结构成像。这些方法要求植入式设备以高时空分辨率将光递送到神经组织的深度。为了满足这一需求,最近设计了刚性和柔性神经光子植入物。本文综述了最先进的柔性无源和有源穿透光学神经探针开发的光传输与组织损伤最小。被动和主动灵活的神经光子植入物进行了比较,并提供了有关未来发展方向的见解。
Understanding the neural basis of brain function and dysfunction and designing effective therapeutics require high resolution targeted stimulation and recording of neural activity. Optical methods have been recently developed for neural stimulation as well as functional and structural imaging. These methods call for implantable devices to deliver light into the neural tissue at depth with high spatiotemporal resolution. To address this need, rigid and flexible neurophotonic implants have been recently designed. This article reviews the state-of-the-art flexible passive and active penetrating optical neural probes developed for light delivery with minimal damage to the tissue. Passive and active flexible neurophotonic implants are compared and insights about future directions are provided.
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